Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ALPPL2 contributors: - updated : 22-11-2005
HGNC name alkaline phosphatase, placental-like 2
HGNC id 441
Location 2q37      Physical location : 233.271.551 - 233.275.422
Synonym name
  • testicular and thymus alkaline phosphatase
  • Nagao isozyme
  • germ cell alkaline phosphatase
    • Synonym symbol(s) ALPG, GCAP, ALPPL
    EC.number 3.1.3.1
    DNA
    TYPE like-sequence
    STRUCTURE 3.00 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus    
    Reproductivemale systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines germ cells tumor lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one active site,
  • two zinc Zn2+ molecules, and magnesium Mg2+ as a cofactor
    • conjugated MetalloP
    mono polymer homomer , dimer
    HOMOLOGY
    intraspecies paralog to ACPP,ALPL
    Homologene
    FAMILY alkaline phosphatase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text attached to the membrane by a gpi-anchor
    basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component complex of identical subunits
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • zinc Zn2+ binding
  • magnesium Mg2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    aberrantly expressed in seminoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS