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FLASH GENE
Symbol ALPI contributors: np/ - updated : 02-02-2004
HGNC name alkaline phosphatase, intestinal
HGNC id 437
Location 2q37.1      Physical location : 233.320.832 - 233.324.740
Synonym name
  • alkaline phosphomonoesterase
  • Kasahara isozyme
  • Synonym symbol(s) IAP
    EC.number 3.1.3.1
    DNA
    TYPE functioning gene
    STRUCTURE 3.91 kb     11 Exon(s)    RaaLrInLh Copie(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    MGC43122 2q37.1 hypothetical protein MGC43122 GPR66 2q37.1 G protein-coupled receptor 66 LOC391490 2 similar to 60S ribosomal protein L23a MGC35154 2q37.1 hypothetical protein MGC35154 MGC4771 2q37.1 hypothetical protein MGC4771 PTMA 2q36-q36 prothymosin, alpha (gene sequence 28) PDE6D 2q36 phosphodiesterase 6D, cGMP-specific, rod, delta COPS7B 2q36.2 COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis) LOC391491 2 similar to guanidinoacetate methyltransferase; GAMT NPPC 2q24-qter natriuretic peptide precursor C MGC42174 2q37.1 hypothetical protein MGC42174 ALPP 2q37.1 alkaline phosphatase, placental (Regan isozyme) ALPPL2 2q37 alkaline phosphatase, placental-like 2 LOC391492 2 similar to xce ALPI 2q37.1 alkaline phosphatase, intestinal ECEL1 2q36-q37 endothelin converting enzyme-like 1 LOC389083 2 similar to enterokinase CHRND 2q37 cholinergic receptor, nicotinic, delta polypeptide CHRNG 2q37.1-q37.2 cholinergic receptor, nicotinic, gamma polypeptide TIGD1 2q36.1 tigger transposable element derived 1 EIF4EL3 2q37.3 eukaryotic translation initiation factor 4E-like 3 FLJ13612 TNRC15 2q37.1 trinucleotide repeat containing 15 KCNJ13 2q37 potassium inwardly-rectifying channel, subfamily J, member 13 LOC389084 2 similar to ASCL830 NGEF 2q37 neuronal guanine nucleotide exchange factor NEU2 2q37 sialidase 2 (cytosolic sialidase) INPP5D 2q36-q37.1 inositol polyphosphate-5-phosphatase, 145kDa APG16L 2q37.1 APG16 autophagy 16-like (S. cerevisiae)
    RNA
    TRANSCRIPTS type untranslated
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2559 54.7 528 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • zinc-metalloprotein, made of a complex of identical subunits, each subunit containing one active site
  • two zinc Zn2+ molecules, and magnesium Mg2+as a cofactor
  • conjugated MetalloP
    mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • alkaline phosphatase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text Attached to the membrane by a GPI-anchor
    basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • Zn2+
  • Mg2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS