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FLASH GENE

Symbol

ALOXE3

contributors: np/ - updated : 28-09-2013

HGNC name	arachidonate lipoxygenase 3
HGNC id	13743

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	ARCI3 ichthyosis, congenital, autosomal recessive 3
Location	17p13.1      Physical location : 7.999.218 - 8.022.234
Synonym name	epidermal lipoxygenase 3
Synonym symbol(s)	MGC119694, MGC119695, MGC119696, e-LOX-3, ELOX3, E-LOX
EC.number	1.13.11.-

DNA

TYPE	like-sequence
SPECIAL FEATURE	arranged in tandem, component of a cluster
text	arranged in a head-to-tail fashion separated by 8.5 kb with ALOX12B
STRUCTURE	23.02 kb     16 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	pter - ALOX15B - ALOX15P - ALOX12B - ALOXE3 - cen
Authors	Krieg(01)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001165960 16 - 3415 NP_001159432 - 843 - - NM_021628 16 - 3251 NP_067641 - 711 - -

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Urinary bladder           kidney         Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining       Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cells

System Cell Pubmed Species Stage Rna symbol not specific adipocyte Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	characteristic segment of 41 aa wich be located beyond the N terminal beta barrel domain at the surface of the C terminal catalyting domain
	PLAT/LH2 domain

HOMOLOGY

interspecies

ortholog to murine Aloxe3

intraspecies	homolog to ALOX12B
	homolog to ALOX15B

Homologene

FAMILY

lipoxygenase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	first step of leukotrienes synthesis from arachidonate
	introducing molecular oxygen into polyunsaturated fatty acids
	synergistic action with XDH, group of oxidized fatty acids which can function as PPAR{gamma} activators

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

inflammation , electron transport

PATHWAY

metabolism

lipid/lipoprotein

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	iron Fe2+

protein

functional link with ALOX12 in normal differentiation of the epidermis

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

ARCI3

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS