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FLASH GENE
Symbol ALOX5AP contributors: mct - updated : 26-05-2008
HGNC name arachidonate 5-lipoxygenase-activating protein
HGNC id 436
Location 13q12-q13      Physical location : 31.309.668 - 31.338.556
Synonym name MK-886-binding protein
Synonym symbol(s) FLAP
DNA
TYPE functioning gene
STRUCTURE 28.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Map cen - D13S283 - D13S221 - D13S289 - ALOX5AP - D13S290 - qter
Authors Yandava (99)
Physical map
PAN3 13q12.2 PABP1-dependent poly A-specific ribonuclease subunit PAN3 FLT1 13q12 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) LOC341784 13q12.3 similar to eukaryotic translation initiation factor 4A1; initiation factor eIF-4A long form C13orf12 13q12.13 chromosome 13 open reading frame 12 LOC283537 13q12.3 hypothetical protein LOC283537 CYP51P2 13 hypothetical protein LOC283537 KIAA0774 13q12.13-q12.2 hypothetical protein LOC283537 SLC7A1 13q12.3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 UBL3 13q12-q13 ubiquitin-like 3 MGC2599 13q12.3 hypothetical protein MGC2599 similar to katanin p60 subunit A 1 2599 PRDX2P1 13p12 peroxiredoxin 2 pseudogene 1 UBCH7N2 13q12.3 ubiquitin-conjugating enzyme-like HMGB1 13q12 high-mobility group box 1 LOC390392 13 similar to Protein-tyrosine phosphatase, non-receptor type 2 (T-cell protein-tyrosine phosphatase) (TCPTP) D13S106E 13q12-q14 highly charged protein ALOX5AP 13q12 arachidonate 5-lipoxygenase-activating protein LOC387917 13 LOC387917 FLJ14834 13q12.3 hypothetical protein FLJ14834 MGC40178 13q12.3 hypothetical protein MGC40178 HSPH1 13q12.3 heat shock 105kDa/110kDa protein 1 B3GTL 13q12.3 beta 3-glycosyltransferase-like GREAT 13q12.3 beta 3-glycosyltransferase-like LOC196549 13q12.3 similar to hypothetical protein FLJ20897 13CDNA73 13q12.3 hypothetical protein CG003 BRCA2 13q12.3 breast cancer 2, early onset IFIT1P 13q12-q13 interferon-induced protein with tetratricopeptide repeats 1, pseudogene CG018 13q12-q13 hypothetical gene CG018 PRO0297 13q12-q13 hypothetical gene CG018 LOC88523 13q12.3 CG016 CG005 APRIN 13q12.3 androgen-induced proliferation inhibitor LOC122038 13q13.1 similar to Mitochondrial import receptor subunit TOM22 homolog (Translocase of outer membrane 22 kDa subunit homolog) (hTom22) (1C9-2) KL 13q12 klotho LOC387918 13 LOC387918 STARD13 13q12-q13 START domain containing 13
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 873 - 161 - Assimes (2008)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas   highly
Respiratorylung   highly
Visualeye   highly
cell lineage cells of myeloid origin
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
hydrophobic integral membrane protein
HOMOLOGY
Homologene
FAMILY
  • GST superfamily
  • MAPEG family of membrane associated proteins in eicosanoid and glutathione metabolism
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • could play an essential role in the transfer of arachidonic acid to 5-lipoxygenase
  • involved in the pathogenesis of both myocardial infarction and stroke by increasing leukotriene production and inflammation in the arterial wall
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • translocating lipoxygenase ALOX5 to plasma membrane and activating it
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to myocardial infarction
  • to ischemic stroke and ischemic stroke subtypes among whites (minor role)
  • Variant & Polymorphism SNP , other
  • increasing the risk of myocardial infarction
  • significant association of variants with ischemic stroke and ischemic stroke subtypes among whites
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS