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FLASH GENE
Symbol ALOX5 contributors: mct - updated : 07-06-2018
HGNC name arachidonate 5-lipoxygenase
HGNC id 435
Location 10q11.21      Physical location : 45.869.628 - 45.941.561
Synonym name
  • leukotriene A4 synthase
  • 5-lipoxygenase
  • Synonym symbol(s) LXG, LOX5, LOG5, 5-LO, 5-LOX, 5LPG, LOG5, MGC163204
    EC.number 1.13.11.34
    DNA
    TYPE functioning gene
    STRUCTURE 71.93 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    motif repetitive sequence   other
    text structure tandem Sp1 binding motifs
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 2568 - 674 - Assimes (2008)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
     tonsils   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • PLAT/LH2 domain
  • N terminal lipoxigenase homology 2 (beta barrel) domain (residues 1114)
  • C2-like domain, a genuine Ca(2+)-dependent membrane-targeting domain, for the specific targeting to the nuclear envelope
  • a C-terminal catalytic domain (residues 121673)(Radmark 2010)
  • secondary structure catalytic domain, composed of several alpha-helices, binds the prosthetic iron (Radmark 2010)
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to murine Alox5
    Homologene
    FAMILY
  • lipoxigenase family
  • CATEGORY enzyme , immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    intracellular,nuclear envelope
    text activation involves its calcium-dependent translocation to the nuclear envelope
    basic FUNCTION
  • catalyzing the first step of leukotrienes biosynthesis from arachidonate
  • lipid peroxidating enzyme implicated in the pathogenesis of inflammatory disorders as well as membrane remodeling
  • carcinogenesis, atheroma and asthma
  • catalyzes two steps in the biosynthesis of leukotrienes (LTs), lipid mediators of inflammation derived from arachidonic acid (Radmark 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • iron Fe2+
  • protein
  • interacting with COTL1 (binds ALOX5 and promotes leukotrienes formation) (Esser 2009)
  • cell & other
    REGULATION
    activated by binding ALOX5AP and translocated to plasma membrane
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate cancer with poor prognosis
    Susceptibility to atherosclerosis
    Variant & Polymorphism other increasing the risk of atheroscleosis
    Candidate gene
    Marker
  • dysregulated levels of ALOX5 may be involved in sepsis pathophysiology and may be utilized as potential diagnostic biomarkers
  • Therapy target
    SystemTypeDisorderPubmed
    digestiveliver 
    melatonin directly suppresses hepatic stellate cells (HSC) activation via RORA-mediated inhibition of ALOX5 expression, which provides novel drug targets to treat liver fibrosis
    cancerhemopathy 
    removing and inhibiting ALOX5, prompting us to test this novel therapeutic strategy in human individuals with CML in the future
    ANIMAL & CELL MODELS