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FLASH GENE

Symbol

ALOX15B

contributors: - updated : 21-04-2005

HGNC name	arachidonate 15-lipoxygenase, second type
HGNC id	434

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17p13.1      Physical location : 7.942.357 - 7.952.442
Synonym symbol(s)	15-LOX-2

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	10.00 kb     14 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	cytosine-phosphate-guanine/HTF
	Binding site
text structure	several Sp1 sites (i.e., three GC boxes and one CACCC box) in the proximal promoter region playing a critical role in regulating ALOX15B expression in prostate cells

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed 15-LOX2 - - 2031 - 676 - Tang 15-LOX2sv-b - splicing 1809 - 602 - Tang show neither nuclear protein localization nor AA-metabolizing activity suppressing prostate tumor development 15-LOX2sv-a - splicing 1944 - 647 - Tang 15-LOX2sv-c - splicing 2111 - 617 - Tang

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system prostate     highly Respiratory lung         Skin/Tegument skin appendages hair follicle     Visual eye anterior segment cornea

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a potential bi-partite nuclear localization signal (NLS) at the N-terminus
	PLAT/LHA2 domain

HOMOLOGY

intraspecies

homolog to ALOXE3

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton
	intracellular,nucleus

basic FUNCTION	catalyzing the first step of leukotrienes from arachidonate
	suppressing prostate tumor development, and the tumor-suppressive functions apparently not depending on AA-metabolizing activity and nuclear localization

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

inflammation

PATHWAY

metabolism

lipid/lipoprotein

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	iron Fe2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS