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FLASH GENE
Symbol ALOX15 contributors: mct/npt - updated : 16-03-2011
HGNC name arachidonate 15-lipoxygenase
HGNC id 433
Location 17p13.1      Physical location : 4.534.220 - 4.544.960
Synonym name arachidonate omega-6 lipoxygenase
Synonym symbol(s) LOG15, 15-LOX-1, 15-LOX2
EC.number 1.13.11.33
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 10.75 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 2707 74.8 662 - McCaskie (2008)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth    
Lymphoid/Immunelymph node    
Respiratoryrespiratory tracttrachea   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticeosinophil
Blood/Hematopoieticleukocyte
Blood/Hematopoieticmonocyte Homo sapiens
Lymphoid/Immunemacrophage
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Alox15
Homologene
FAMILY
  • lipoxygenase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • non-heme iron containing dioxygenase, catalyzing the first step of leukotrienes biosynthesis from arachidonate
  • lipid peroxidating enzyme implicated in the pathogenesis of inflammatory disorders as well as membrane remodeling
  • involved in carcinogenesis, and atheroma formation
  • maybe involved in the development of prostate or intestines colorectal carcinomas
  • involved in the translational control and stabilization of mRNAs in erythroid cells
  • cardiac ALOX12/ALOX15 is involved in the development of heart failure
  • ALOX12/ALOX15 mediates early stages of adipose tissue inflammation and whole body insulin resistance induced by high fat feeding
  • ALOX12/ALOX15 is required for the maintenance of long-term hematopoietic stem cells quiescence and number
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • iron Fe2+
  • protein
  • binding site for SPI1 (increasing its transcription in the macrophage)
  • vimentin binds the ALOX15 promoter and regulates its promoter activity and protein expression
  • cell & other
    REGULATION
    Other regulated by ERK1/2 (important regulatory role for ERK1/2 in mediating IL13-induced monocyte ALOX15 expression via the transcription factors EGR1 and CREB)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostatic adenocarcinoma
    constitutional     --over  
    in heart failure
    tumoral     --other  
    expressed in primary Hodgkin Reed-Sternberg cells in classical Hodgkin lymphoma
    Susceptibility to coronary artery disease (CAD)
    Variant & Polymorphism SNP
  • rs7217186:T>C and rs2619112:G>A of ALOX15 are associated with increased risk of CAD
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cardiovascularaquired 
    inhibition of ALOX12/ALOX15 could be a novel treatment for heart failure
    immunologyinfectious 
    ALOX15 pathway is a novel therapeutic target for the treatment of virus-associated asthma characterized by Th1 inflammation
    ANIMAL & CELL MODELS
  • Cardiac fibrosis increased in Alox15 transgenic mice with advancing age and was associated with the infiltration of macrophages