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FLASH GENE
Symbol ALOX15 contributors: mct/npt - updated : 16-03-2011
HGNC name arachidonate 15-lipoxygenase
HGNC id 433
Location 17p13.1      Physical location : 4.534.220 - 4.544.960
Synonym name arachidonate omega-6 lipoxygenase
Synonym symbol(s) LOG15, 15-LOX-1, 15-LOX2
EC.number 1.13.11.33
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 10.75 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
UBE2G1 1q42 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans) MGC29671 17p13.3 hypothetical protein MGC29671 LOC124976 17p13.3 hypothetical protein LOC124976 MYBBP1A 17p13.3 MYB binding protein (P160) 1a FLJ90165 17p13.3 hypothetical protein FLJ90165 LOC124974 17p13.3 thioredoxin 1 pseudogene 4 FLJ42461 17p13.3 FLJ42461 protein ALOX15 17p13.1 arachidonate 15-lipoxygenase PELP1 17p13.3 arachidonate 15-lipoxygenase LOC390758 17 similar to 40S RIBOSOMAL PROTEIN S12 ARRB2 17p13 arrestin, beta 2 CXCL16 17p13 chemokine (C-X-C motif) ligand 16 LOC388322 17 similar to HSPC296 ZMYND15 17p13.3 zinc finger, MYND domain containing 15 TM4SF5 17p13.3 transmembrane 4 superfamily member 5 LOC284013 17p13.3 secretory protein LOC284013 LOC388323 17 similar to RIKEN cDNA C730027E14 PSMB6 17p13 proteasome (prosome, macropain) subunit, beta type, 6 PLD2 17p13.1 phospholipase D2 LOC284015 17p13.3 similar to Vacuolar ATP synthase 16 kDa proteolipid subunit MINK 17p13 similar to Vacuolar ATP synthase 16 kDa proteolipid subunit CHRNE 17p13.1 cholinergic receptor, nicotinic, epsilon polypeptide GP1BA 17pter-p12 glycoprotein Ib (platelet), alpha polypeptide SLC25A11 17p13.3 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 DKFZP566H073 17p13.3 DKFZP566H073 protein PFN1 17p13.3 profilin 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 2707 74.8 662 - McCaskie (2008)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth    
Lymphoid/Immunelymph node    
Respiratoryrespiratory tracttrachea   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticeosinophil
Blood/Hematopoieticleukocyte
Blood/Hematopoieticmonocyte Homo sapiens
Lymphoid/Immunemacrophage
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Alox15
Homologene
FAMILY
  • lipoxygenase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • non-heme iron containing dioxygenase, catalyzing the first step of leukotrienes biosynthesis from arachidonate
  • lipid peroxidating enzyme implicated in the pathogenesis of inflammatory disorders as well as membrane remodeling
  • involved in carcinogenesis, and atheroma formation
  • maybe involved in the development of prostate or intestines colorectal carcinomas
  • involved in the translational control and stabilization of mRNAs in erythroid cells
  • cardiac ALOX12/ALOX15 is involved in the development of heart failure
  • ALOX12/ALOX15 mediates early stages of adipose tissue inflammation and whole body insulin resistance induced by high fat feeding
  • ALOX12/ALOX15 is required for the maintenance of long-term hematopoietic stem cells quiescence and number
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • iron Fe2+
    • protein
  • binding site for SPI1 (increasing its transcription in the macrophage)
  • vimentin binds the ALOX15 promoter and regulates its promoter activity and protein expression
    • cell & other
    REGULATION
    Other regulated by ERK1/2 (important regulatory role for ERK1/2 in mediating IL13-induced monocyte ALOX15 expression via the transcription factors EGR1 and CREB)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostatic adenocarcinoma
    constitutional     --over  
    in heart failure
    tumoral     --other  
    expressed in primary Hodgkin Reed-Sternberg cells in classical Hodgkin lymphoma
    Susceptibility to coronary artery disease (CAD)
    Variant & Polymorphism SNP
  • rs7217186:T>C and rs2619112:G>A of ALOX15 are associated with increased risk of CAD
    • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cardiovascularaquired 
    inhibition of ALOX12/ALOX15 could be a novel treatment for heart failure
    immunologyinfectious 
    ALOX15 pathway is a novel therapeutic target for the treatment of virus-associated asthma characterized by Th1 inflammation
    ANIMAL & CELL MODELS
  • Cardiac fibrosis increased in Alox15 transgenic mice with advancing age and was associated with the infiltration of macrophages