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FLASH GENE
Symbol ALOX15 contributors: mct/npt - updated : 07-02-2023
HGNC name arachidonate 15-lipoxygenase
HGNC id 433
Location 17p13.2      Physical location : 4.534.220 - 4.544.960
Synonym name
  • arachidonate omega-6 lipoxygenase
  • 15-lipoxygenase type 1
  • arachidonate 12-lipoxygenase, leukocyte-type
    • Synonym symbol(s) LOG15, 15-LOX-1, 15-LOX2, 12-LOX
    EC.number 1.13.11.33/ 1.13.11.12
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 10.75 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 2707 74.8 662 - 2020 33218117
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth    
    Lymphoid/Immunelymph node    
    Respiratoryrespiratory tracttrachea    Homo sapiens
     respiratory tractbronchiole    Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose   
    Epithelialabsorptive excretoryalveolar epithelium   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticeosinophil
    Blood/Hematopoieticleukocyte
    Blood/Hematopoieticmonocyte Homo sapiens
    Lymphoid/Immunemacrophage Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Alox15
    Homologene
    FAMILY
  • lipoxygenase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • non-heme iron containing dioxygenase, catalyzing the first step of leukotrienes biosynthesis from arachidonate
  • lipid peroxidating enzyme implicated in the pathogenesis of inflammatory disorders as well as membrane remodeling
  • involved in carcinogenesis, and atheroma formation
  • maybe involved in the development of prostate or intestines colorectal carcinomas
  • involved in the translational control and stabilization of mRNAs in erythroid cells
  • cardiac ALOX12/ALOX15 is involved in the development of heart failure
  • ALOX12/ALOX15 mediates early stages of adipose tissue inflammation and whole body insulin resistance induced by high fat feeding
  • ALOX12/ALOX15 is required for the maintenance of long-term hematopoietic stem cells quiescence and number
  • pivotal role of ALOX15 in the resolution of adipocyte death and in adipose tissue remodeling
  • plays an important role in the formation of key lipid mediators (e.g., lipoxins and resolvins) to terminate inflammation
  • most mammalian ALOX15 orthologs exhibit dual positional specificity with highly unsaturated n-3 polyunsaturated fatty acids
  • functions to generate specific phospholipid (PL) oxidation products crucial for orchestrating the nonimmunogenic removal of apoptotic cells (ACs)
  • ALOX15 plays a significant role in promoting the migration of immune cells, such as immature dendritic cells, activated T cells, and mast cells, and airway remodeling, including goblet cell differentiation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • iron Fe2+
    • protein
  • binding site for SPI1 (increasing its transcription in the macrophage)
  • vimentin binds the ALOX15 promoter and regulates its promoter activity and protein expression
  • methylated HNRNPK acts on RPS19 to regulate ALOX15 synthesis in erythropoiesis
    • cell & other
    REGULATION
    Other regulated by ERK1/2 (important regulatory role for ERK1/2 in mediating IL13-induced monocyte ALOX15 expression via the transcription factors EGR1 and CREB)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostatic adenocarcinoma
    constitutional     --over  
    in heart failure
    tumoral     --other  
    expressed in primary Hodgkin Reed-Sternberg cells in classical Hodgkin lymphoma
    tumoral       loss of function
    in colorectal cancer (CRC)
    Susceptibility
  • to coronary artery disease (CAD)
  • to bone loss, fracture incidence
  • to nasal polyps and chronic rhinosinusitis
    • Variant & Polymorphism SNP , other
  • rs7217186:T>C and rs2619112:G>A of ALOX15 are associated with increased risk of CAD
  • variation in ALOX15 was associated with bone microarchitecture and density in young adult women, but appears to be less important in the elderly
  • a loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis
    • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cardiovascularaquired 
    inhibition of ALOX12/ALOX15 could be a novel treatment for heart failure
    immunologyinfectious 
    ALOX15 pathway is a novel therapeutic target for the treatment of virus-associated asthma characterized by Th1 inflammation
    ANIMAL & CELL MODELS
  • Cardiac fibrosis increased in Alox15 transgenic mice with advancing age and was associated with the infiltration of macrophages
  • Mice lacking Alox15 in &
    • 946; cells exhibit an increase in a population of beta cells expressing the gene encoding the protein programmed death ligand 1 (PD-L1), which engages receptors on immune cells to sssuppress autoimmunity