basic FUNCTION
| non-heme iron containing dioxygenase, catalyzing the first step of leukotrienes biosynthesis from arachidonate |
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lipid peroxidating enzyme implicated in the pathogenesis of inflammatory disorders as well as membrane remodeling |
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involved in carcinogenesis, and atheroma formation |
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maybe involved in the development of prostate or intestines colorectal carcinomas |
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involved in the translational control and stabilization of mRNAs in erythroid cells |
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cardiac ALOX12/ALOX15 is involved in the development of heart failure  |
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ALOX12/ALOX15 mediates early stages of adipose tissue inflammation and whole body insulin resistance induced by high fat feeding  |
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ALOX12/ALOX15 is required for the maintenance of long-term hematopoietic stem cells quiescence and number  |