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FLASH GENE

Symbol

ALOX15

contributors: mct/npt - updated : 16-03-2011

HGNC name	arachidonate 15-lipoxygenase
HGNC id	433

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17p13.1      Physical location : 4.534.220 - 4.544.960
Synonym name	arachidonate omega-6 lipoxygenase
Synonym symbol(s)	LOG15, 15-LOX-1, 15-LOX2
EC.number	1.13.11.33

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	10.75 kb     14 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001140 14 - 2707 74.8 662 - McCaskie (2008)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth         Lymphoid/Immune lymph node         Respiratory respiratory tract trachea

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic eosinophil Blood/Hematopoietic leukocyte Blood/Hematopoietic monocyte Homo sapiens Lymphoid/Immune macrophage

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine Alox15

Homologene

FAMILY

lipoxygenase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus

basic FUNCTION	non-heme iron containing dioxygenase, catalyzing the first step of leukotrienes biosynthesis from arachidonate
	lipid peroxidating enzyme implicated in the pathogenesis of inflammatory disorders as well as membrane remodeling
	involved in carcinogenesis, and atheroma formation
	maybe involved in the development of prostate or intestines colorectal carcinomas
	involved in the translational control and stabilization of mRNAs in erythroid cells
	cardiac ALOX12/ALOX15 is involved in the development of heart failure
	ALOX12/ALOX15 mediates early stages of adipose tissue inflammation and whole body insulin resistance induced by high fat feeding
	ALOX12/ALOX15 is required for the maintenance of long-term hematopoietic stem cells quiescence and number

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

inflammation

PATHWAY

metabolism

lipid/lipoprotein

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	iron Fe2+

protein	binding site for SPI1 (increasing its transcription in the macrophage)
	vimentin binds the ALOX15 promoter and regulates its promoter activity and protein expression

cell & other

REGULATION

Other

regulated by ERK1/2 (important regulatory role for ERK1/2 in mediating IL13-induced monocyte ALOX15 expression via the transcription factors EGR1 and CREB)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in prostatic adenocarcinoma constitutional     --over   in heart failure tumoral     --other   expressed in primary Hodgkin Reed-Sternberg cells in classical Hodgkin lymphoma

Susceptibility

to coronary artery disease (CAD)

Variant & Polymorphism SNP	rs7217186:T>C and rs2619112:G>A of ALOX15 are associated with increased risk of CAD

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cardiovascular aquired   inhibition of ALOX12/ALOX15 could be a novel treatment for heart failure immunology infectious   ALOX15 pathway is a novel therapeutic target for the treatment of virus-associated asthma characterized by Th1 inflammation

ANIMAL & CELL MODELS

Cardiac fibrosis increased in Alox15 transgenic mice with advancing age and was associated with the infiltration of macrophages