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FLASH GENE
Symbol ALOX12B contributors: mct - updated : 02-02-2007
HGNC name arachidonate 12-lipoxygenase, 12R type
HGNC id 430
Corresponding disease
NCIE3B non bullous congenital ichthyosiform erythroderma 3B
Location 17p13.1      Physical location : 7.975.953 - 7.991.021
Synonym name epidermis-type lipoxygenase 12
Synonym symbol(s) LOXR, 12R-LOX
EC.number 1.13.11.-
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem, component of a cluster
text arranged in a head-to-tail fashion separated by 8.5 kb with ALOX12B
STRUCTURE 15.00 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
ATP1B2 17p13.1 ATPase, Na+/K+ transporting, beta 2 polypeptide TP53 17p13.1 tumor protein p53 (Li-Fraumeni syndrome) FLJ10385 17p13.2 hypothetical protein FLJ10385 EFNB3 17p13.1-p11.2 ephrin-B3 LOC284158 17p13.2 similar to KIAA1503 protein FLJ46675 17p13.2 FLJ46675 protein KIAA0346 17p13.1-p12 FLJ46675 protein LOC92162 17p13.2 similar to RIKEN cDNA 2600017H02 MGC14151 17p13.2 hypothetical protein MGC14151 FLJ32499 17p13.2 hypothetical protein FLJ32499 LOC388331 17 LOC388331 KCNAB3 17p13.1 potassium voltage-gated channel, shaker-related subfamily, beta member 3 TRAPPC1 17p13.1 trafficking protein particle complex 1 LIP8 17p13.2 LYST-interacting protein LIP8 GUCY2D 17p13.1 guanylate cyclase 2D, membrane (retina-specific) ALOX15B 17p13.1 arachidonate 15-lipoxygenase, second type LOC388332 17 similar to Gag protein ALOX12B 17p13.1 arachidonate 12-lipoxygenase, 12R type ALOXE3 17p13.1 arachidonate lipoxygenase 3 HES7 17p13.1 hairy and enhancer of split 7 (Drosophila) PER1 17p13.1-p12 period homolog 1 (Drosophila) VAMP2 17p13.1-p12 vesicle-associated membrane protein 2 (synaptobrevin 2) MGC10744 17p13.1 hypothetical protein MGC10744 FLJ20014 17p13.1 hypothetical protein FLJ20014 AURKB 17p13.1 aurora kinase B FLJ34790 17p13.1 hypothetical protein FLJ34790 FLJ22170 17p13.1 hypothetical protein FLJ22170 PFAS 17p13 phosphoribosylformylglycinamidine synthase (FGAR amidotransferase) RANGNRF 17p13 RAN guanine nucleotide release factor ARHGEF15 17p12 Rho guanine nucleotide exchange factor (GEF) 15 ODF4 17p12 outer dense fiber of sperm tails 4
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx    
Lymphoid/Immunelymph node    
Reproductivefemale systemuteruscervix  
Skin/Tegumentskin    
Urinarybladder    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneB cell
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a PLAT/LH2 domain (beta-barrel domain)
HOMOLOGY
interspecies ortholog to murine Alox12b
ortholog to chimpanzee alox12b
intraspecies homolog to ALOX15B
homolog to ALOXE3
Homologene
FAMILY lipoxygenase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • first step of leukotrienes synthesis from arachidonate
  • converting arachidonic acid to 12R-hydroperoxy eicosatetraenoic acid (12R-HPETE)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , inflammation , endocytosis transport , electron transport
    text
  • epidermis development
  • PATHWAY
    metabolism lipid/lipoprotein
    signaling
  • leukotriene biosynthesis
  • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    iron Fe2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NCIE3B
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS