Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

ALOX12B

contributors: mct - updated : 02-02-2007

HGNC name	arachidonate 12-lipoxygenase, 12R type
HGNC id	430

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	NCIE3B non bullous congenital ichthyosiform erythroderma 3B
Location	17p13.1      Physical location : 7.975.953 - 7.991.021
Synonym name	epidermis-type lipoxygenase 12
Synonym symbol(s)	LOXR, 12R-LOX
EC.number	1.13.11.-

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem, component of a cluster
text	arranged in a head-to-tail fashion separated by 8.5 kb with ALOX12B
STRUCTURE	15.00 kb     15 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pharynx         Lymphoid/Immune lymph node         Reproductive female system uterus cervix     Skin/Tegument skin         Urinary bladder

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining       Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune B cell Skin/Tegument keratinocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a PLAT/LH2 domain (beta-barrel domain)

HOMOLOGY

interspecies	ortholog to murine Alox12b
	ortholog to chimpanzee alox12b

intraspecies	homolog to ALOX15B
	homolog to ALOXE3

Homologene

FAMILY

lipoxygenase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	first step of leukotrienes synthesis from arachidonate
	converting arachidonic acid to 12R-hydroperoxy eicosatetraenoic acid (12R-HPETE)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development , inflammation , endocytosis transport , electron transport

text	epidermis development

PATHWAY

metabolism

lipid/lipoprotein

signaling

leukotriene biosynthesis

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	iron Fe2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

NCIE3B

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS