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FLASH GENE
Symbol ALOX12 contributors: mct/npt - updated : 16-03-2011
HGNC name arachidonate 12-lipoxygenase
HGNC id 429
Location 17p13.1      Physical location : 6.899.383 - 6.914.054
Synonym name
  • platelet-type lipoxygenase 12
  • arachidonate 12-lipoxygenase, 12S-type
  • Synonym symbol(s) LXGAS, LOG12, 12-LOX, 12S-LOX, 12R-LOX
    EC.number 1.13.11.31
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 14.00 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    MGC14353 CGI-125 17p13.2 CGI-125 protein LOC388327 17 hypothetical gene supported by BC052606 LOC342531 17p13.2 similar to Arachidonate 15-lipoxygenase (Arachidonate omega-6 lipoxygenase) (15-LOX) SLC13A5 17p13.2 solute carrier family 13 (sodium-dependent citrate transporter), member 5 HSXIAPAF1 17p13.2 XIAP associated factor-1 MGC35179 17p13.2 hypothetical protein MGC35179 TEKT1 17p13.2 tektin 1 ALOX12P2 17p13.1 arachidonate 12-lipoxygenase pseudogene 2 ALOX12 17p13.1 arachidonate 12-lipoxygenase LOC388328 17 LOC388328 MGC49942 17p13.2 hypothetical protein MGC49942 BCL6B 17p13.1 B-cell CLL/lymphoma 6, member B (zinc finger protein) LOC201232 SLC16A11 17p13.2 solute carrier family 16 (monocarboxylic acid transporters), member 11 CLECSF13 2p13.3 likely ortholog of mouse C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 13 ASGR2 17p13.1 asialoglycoprotein receptor 2 ASGR1 17p12 asialoglycoprotein receptor 1 DLG4 17p13.1 discs, large (Drosophila) homolog 4 ACADVL 17p13.1 acyl-Coenzyme A dehydrogenase, very long chain
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 2358 75.7 663 - Mullin (2007)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemovary   
    Skin/Tegumentskin    
    Urinarybladder    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    Lymphoid/ImmuneB cell
    cell lineage
    cell lines erythroleukemia cells
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text umbilical vein
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • lipoxygenase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • catalyzing the first step of leukotrienes biosynthesis from arachidonate
  • lipid peroxidating enzyme implicated in the pathogenesis of inflammatory disorders as well as membrane remodeling
  • carcinogenesis and atheroma formation
  • cardiac ALOX12/ALOX15 is involved in the development of heart failure
  • ALOX12/ALOX15 mediates early stages of adipose tissue inflammation and whole body insulin resistance induced by high fat feeding
  • ALOX12/ALOX15 is required for the maintenance of long-term hematopoietic stem cells quiescence and number
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • functional link with ALOXE3 in normal differentiation of the epidermis
  • direct transcriptional target gene of RUNX1 (Kaur 2010)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to modification of bone mineral density in postmenopausal women (BMD)
    Variant & Polymorphism other polymorphisms in ALOX12, significantly associated with BMD in postmenopausal women
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cardiovascularaquired 
    inhibition of ALOX12/ALOX15 could be a novel treatment for heart failure
    ANIMAL & CELL MODELS