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FLASH GENE
Symbol ALKBH8 contributors: mct/npt - updated : 12-07-2010
HGNC name alkB, alkylation repair homolog 8 (E. coli)
HGNC id 25189
Location 11q22.3      Physical location : 107.373.453 - 107.436.461
Synonym name
  • AlkB homologue 8
  • alkylated DNA repair protein alkB homolog 8
  • Synonym symbol(s) FLJ38204, MGC10235
    DNA
    TYPE functioning gene
    STRUCTURE 63.01 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 4085 - 664 - Songe-Møller (2010)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   highly
    Endocrineneuroendocrine   highly
     pancreas   highly
     thyroid   moderately
    Nervousnervecranial nerve  highly
    Respiratoryrespiratory tracttrachea  predominantly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • characteristic AlkB domain
  • an RNA recognition motif (RRM)
  • an S-adenosylmethionine (SAM)-dependent methyltransferase (MT) domain (Songe-Møller 2010)
  • HOMOLOGY
    Homologene
    FAMILY
  • alkB family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • performs the final methylation step during formation of the wobble uridine modification mcm5U in mammals (Songe-Møller 2010)
  • essential role for ALKBH8 in urothelial carcinoma cell survival (Shimada 2009)
  • CELLULAR PROCESS nucleotide, repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    protein
  • interaction with a small accessory protein, TRM112, required to form a functional tRNA methyltransferase (Songe-Møller 2010)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    silencing of ALKBH8 significantly suppressed invasion, angiogenesis, and growth of bladder cancers (Shimada 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target new therapeutic strategies in human bladder cancer by inducing JNK/p38/gammaH2AX-mediated cell death by silencing of ALKBH8 (Shimada 2009)
    ANIMAL & CELL MODELS