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FLASH GENE

Symbol

ALKBH8

contributors: mct/npt - updated : 12-07-2010

HGNC name	alkB, alkylation repair homolog 8 (E. coli)
HGNC id	25189

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q22.3      Physical location : 107.373.453 - 107.436.461
Synonym name	AlkB homologue 8
	alkylated DNA repair protein alkB homolog 8
Synonym symbol(s)	FLJ38204, MGC10235

DNA

TYPE	functioning gene
STRUCTURE	63.01 kb     12 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_138775 12 - 4085 NP_620130 - 664 - Songe-Møller (2010)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel       highly Endocrine neuroendocrine       highly   pancreas       highly   thyroid       moderately Nervous nerve cranial nerve     highly Respiratory respiratory tract trachea     predominantly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	characteristic AlkB domain
	an RNA recognition motif (RRM)
	an S-adenosylmethionine (SAM)-dependent methyltransferase (MT) domain (Songe-Møller 2010)

HOMOLOGY

Homologene

FAMILY

alkB family

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,ribosome

basic FUNCTION	performs the final methylation step during formation of the wobble uridine modification mcm5U in mammals (Songe-Møller 2010)
	essential role for ALKBH8 in urothelial carcinoma cell survival (Shimada 2009)

CELLULAR PROCESS

nucleotide, repair

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

nucleotide,

protein

interaction with a small accessory protein, TRM112, required to form a functional tRNA methyltransferase (Songe-Møller 2010)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   silencing of ALKBH8 significantly suppressed invasion, angiogenesis, and growth of bladder cancers (Shimada 2009)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	new therapeutic strategies in human bladder cancer by inducing JNK/p38/gammaH2AX-mediated cell death by silencing of ALKBH8 (Shimada 2009)

ANIMAL & CELL MODELS