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FLASH GENE
Symbol ALKBH8 contributors: mct/npt - updated : 21-06-2019
HGNC name alkB, alkylation repair homolog 8 (E. coli)
HGNC id 25189
Corresponding disease
ALKBH8D ALKBH8 deficiency
Location 11q22.3      Physical location : 107.373.453 - 107.436.461
Synonym name
  • AlkB homologue 8
  • alkylated DNA repair protein alkB homolog 8
  • Synonym symbol(s) FLJ38204, MGC10235, ABH8
    EC.number 2.1.1.229
    DNA
    TYPE functioning gene
    STRUCTURE 63.01 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 4085 - 664 - 2010 20308323
    12 - 4038 - 667 - 2010 20308323
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   highly
    Endocrineneuroendocrine   highly
     pancreas   highly
     thyroid   moderately
    Nervousnervecranial nerve  highly
    Respiratoryrespiratory tracttrachea  predominantly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • characteristic AlkB domain
  • an RNA recognition motif (RRM)
  • an S-adenosylmethionine (SAM)-dependent methyltransferase (MT) domain (Songe-Møller 2010), methyltransferase domains flanking its ALKB domain
  • HOMOLOGY
    interspecies ortholog to yeast Trm9
    Homologene
    FAMILY
  • alkB family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus,nucleoplasm,nuclear bodies
    basic FUNCTION
  • performs the final methylation step during formation of the wobble uridine modification mcm5U in mammals (Songe-Møller 2010)
  • essential role for ALKBH8 in urothelial carcinoma cell survival (Shimada 2009)
  • ALKBH8 and tRNA modifications as central regulators of cellular oxidative stress responses in mammalian systems
  • ALKBH1, ALKBH5, ALKBH8 and FTO act as RNA demethylases
  • CELLULAR PROCESS nucleotide, repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    protein
  • interaction with a small accessory protein, TRM112, required to form a functional tRNA methyltransferase (Songe-Møller 2010)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ALKBH8D
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    silencing of ALKBH8 significantly suppressed invasion, angiogenesis, and growth of bladder cancers (Shimada 2009)
    tumoral     --over  
    is critical for the growth and progression of bladder cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target new therapeutic strategies in human bladder cancer by inducing JNK/p38/gammaH2AX-mediated cell death by silencing of ALKBH8 (Shimada 2009)
    ANIMAL & CELL MODELS