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FLASH GENE
Symbol ALKBH5 contributors: mct - updated : 03-09-2014
HGNC name alkB, alkylation repair homolog 5 (E. coli)
HGNC id 25996
Location 17p11.2      Physical location : 18.086.866 - 18.113.265
Synonym name
  • oxoglutarate and iron-dependent oxygenase domain containing
  • alkylated DNA repair protein alkB homolog 5
  • probable alpha-ketoglutarate-dependent dioxygenase ABH5
  • alpha-ketoglutarate-dependent dioxygenase alkB homolog 5
  • Synonym symbol(s) OFOXD, OFOXD1, FLJ20308
    EC.number 1.14.11.-
    DNA
    TYPE functioning gene
    STRUCTURE 26.40 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 3449 - 394 - 2002 1199733
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon moderately
     mouthtongue  moderately
     pancreas exocrine   moderately
     salivary gland   predominantly
    Endocrineparathyroid   highly
    Lymphoid/Immunelymph node   highly
     tonsils   moderately
    Reproductivefemale systemuterus  moderately
    Respiratoryrespiratory tractlarynx  moderately
    Skin/Tegumentskin   moderately
    Urinarykidney   moderately
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a distinct "lid" region playing a vital role in substrate recognition and catalysis
  • a catalytic domain that can demethylate both single-stranded RNA and single-stranded DNA
  • secondary structure has a double-stranded beta-helix core fold as observed in other 2OG and iron-dependent oxygenase family members
    HOMOLOGY
    Homologene
    FAMILY
  • iron/ascorbate-dependent oxidoreductase family
  • AlkB family of dioxygenases
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • acting as an oxidoreductase
  • may have a role in the regulation of cellular responses to hypoxia
  • demethylase that oxidatively reverses N(6)-methyladenosine (m(6)A) in mRNA
  • 2-oxoglutarate (2OG) and ferrous iron-dependent nucleic acid oxygenase (NAOX) that catalyzes the demethylation of N(6)-methyladenine in RNA
  • plays a role in spermatogenesis
  • compared with other AlkB proteins, displays several unique structural features on top of the conserved double-stranded beta-helix fold typical of this protein family
  • CELLULAR PROCESS nucleotide, repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Fe2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Alkbh5-deficient male mice have increased N(6)-methyladenosine (m(6)A) in mRNA and are characterized by impaired fertility resulting from apoptosis that affects meiotic metaphase-stage spermatocytes