Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ALKBH1 contributors: mct - updated : 26-06-2019
HGNC name alkB, alkylation repair homolog 1 (E. coli)
HGNC id 17911
Location 14q24.3      Physical location : 78.138.748 - 78.174.356
Synonym name
  • putative DNA alkylation damage repair gene non receptor, homologous to E coli AlkB
  • alkB, alkylation repair homolog (E. coli)
  • alkylated DNA repair protein alkB homolog
  • Synonym symbol(s) alkB, ABH, ALKBH, ABH1, hABH1
    DNA
    TYPE functioning gene
    STRUCTURE 35.00 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 2585 43 389 - -
  • 6 exons
  • - splicing 2422 12 116 - -
  • lacking an in-frame segment of the coding region compared to variant 1
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   predominantly
    Digestiveintestinesmall intestine  moderately
     stomach   highly
    Endocrineadrenal gland   highly
    Lymphoid/Immunelymph node   moderately
    Nervousnerve   highly
    Reproductivefemale systemuteruscervix moderately
    Respiratorylung   moderately
     respiratory tractlarynx  highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal predominantly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to E.coli AlkB
    Homologene
    FAMILY ALKB family
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • playing a putative role in DNA alkylation damage repair
  • demethylates 3-methylcytosine in single-stranded DNA and RNA and is a functional mitochondrial AlkB homolog that repairs 3-methylcytosine in single-stranded DNA and RNA
  • ALKBH1, ALKBH5, ALKBH8 and FTO act as RNA demethylases
  • CELLULAR PROCESS nucleotide, repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS