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FLASH GENE
Symbol ALKAL2 contributors: mct - updated : 25-10-2019
HGNC name ALK and LTK ligand 2
HGNC id 27683
Location 2p25.3      Physical location : -
Synonym name
  • hypothetical protein LOC285016
  • augmentor-alpha
  • family with sequence similarity 150, member B
  • Synonym symbol(s) PRO1097, RGPG542, AUGA, FAM150B, PRO1097, RGPG542
    DNA
    TYPE functioning gene
    STRUCTURE 9.31 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1184 - 152 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel    
    Endocrineneuroendocrinepituitary   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    Homologene
    FAMILY
  • FAM150 family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • physiological link between augmentor ligands (FAM150A, FAM150B) and LTK and particular augmentors activate LTK in a tissue-specific context to induce iridophore differentiation from neural crest-derived cells and pigment progenitor cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ALKAL1 and ALKAL2 are potent ligands for human ALK that bind to the extracellular domain of ALK and in addition to activation of wild-type ALK are able to drive 'superactivation' of activated ALK mutants from neuroblastoma
  • . ALKAL2 binds ALK with high affinity and activates ALK in cells with subnanomolar potency
  • binds and robustly activates both ALK and LTK
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS