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Symbol ALG6 contributors: mct/npt - updated : 11-09-2009
HGNC name asparagine-linked glycosylation 6, alpha-1,3-glucosyltransferase homolog (S. cerevisiae)
HGNC id 23157
Corresponding disease
CDG1C congenital disorder of glycosylation, type 1C
Location 1p31.3      Physical location : 63.833.260 - 63.904.232
Synonym name
  • asparagine-linked glycosylation 6 homolog (S. cerevisiae, alpha-1,3-glucosyltransferase)
  • asparagine-linked glycosylation 6
  • dolichyl-P-Glc:Man9GlcNAc2-PP-dolichylglucosyltransferase
  • asparagine-linked glycosylation 6 homolog (yeast, alpha-1,3-glucosyltransferase)
    • Synonym symbol(s) My046
    EC.number 2.4.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 70.97 kb     15 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 3371 58 507 - Gregory (2006)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Nervousbrain    
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to yeast S.cerevisiae Alg6
    Homologene
    FAMILY
  • ALG6/ALG8 glucosyltransferase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    text by analogy
    basic FUNCTION
  • N linked protein glycosylation of the oligomannose core, dolichyl pyrophosphate-linked Glc3Man9GLc Nac2 synthesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG1C
    related resource Congenital Disorder of Glycosylation pages
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS