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FLASH GENE
Symbol ALDOA contributors: - updated : 16-02-2006
HGNC name aldolase A, fructose-bisphosphate
HGNC id 414
Corresponding disease
ALDOA hemolytic anemia with aldolase deficiency
Location 16q22.2      Physical location : 30.064.490 - 30.081.734
Synonym name
  • fructose-1,6-bisphosphate triosephosphate-lyase
  • muscle-type aldolase
  • lung cancer antigen NY-LU-1
  • Synonym symbol(s) ALDA, MGC10942, MGC17716, MGC17767
    EC.number 4.1.2.13
    DNA
    TYPE functioning gene
    STRUCTURE 17.00 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    FLJ35681 16p12.1 hypothetical protein FLJ35681 ZG16 16p12.1 zymogen granule protein 16 KIF22 16p11.2 kinesin family member 22 MAZ 16p11.2 MYC-associated zinc finger protein (purine-binding transcription factor) LOC112476 16p12.1 similar to lymphocyte antigen 6 complex, locus G5B; G5b protein; open reading frame 31 MGC4606 16p12.1 hypothetical protein MGC4606 MVP 16p11.2 major vault protein CDIPT 16p12.1 CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) PSK-1 16p12.1 type I transmembrane receptor (seizure-related protein) KCTD13 16p11.2 potassium channel tetramerisation domain containing 13 LOC253982 16p12.1 hypothetical protein LOC253982 LOC124446 16p12.1 hypothetical protein BC017488 PSK 16p12.1 hypothetical protein BC017488 TAO1 16p11.2 hypothetical protein BC017488 HIRIP3 16q13 HIRA interacting protein 3 FLJ90652 16p12.1 hypothetical protein FLJ90652 DOC2A 16q13 double C2-like domains, alpha DKFZP434I2117 16p12.1 hypothetical protein DKFZp434I2117 ALDOA 16q22.2 aldolase A, fructose-bisphosphate PPP4C 16p12-p11 protein phosphatase 4 (formerly X), catalytic subunit TBX6 16p11.2 T-box 6 MGC10500 16p12.1 hypothetical protein MGC10500 MGC4171 16p12.1 hypothetical protein MGC4171 MAPK3 16p11.2 mitogen-activated protein kinase 3 CORO1A 16p11.2-q11.2 coronin, actin binding protein, 1A LOC339088 16p12.1 similar to My016 protein SULT1A3 16p11.2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 LOC387619 16 PI-3-kinase-related kinase SMG-1 LOC390689 16 similar to carbonic anhydrase VA, mitochondrial precursor; carbonic anhydrase V, mitochondrial; carbonic dehydratase CD2BP2 16p12.1 CD2 antigen (cytoplasmic tail) binding protein 2 DKFZP434P1750 16p12.1 DKFZP434P1750 protein HUMMLC2B 16p12.1 myosin light chain 2 SEPT1 16q11.1 septin 1 FLJ31751 16p12.1 hypothetical protein FLJ31751
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2353 39.3 364 - Esposito
    - - 1572 - 364 - Esposito
    - - 1594 - 364 - Esposito
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivefemale systemuteruscervix highly
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    cell cycle     cell cycle, M
    Text liver, kidney, small intestine
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , tetramer
    HOMOLOGY
    interspecies ortholog to murine Aldoa
    intraspecies paralog to ALDOC
    Homologene
    FAMILY class I fructose-bisphosphate aldolase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • reversibly cleaving FI-P and FBP to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate , energetic
    signaling
  • glycolysis
  • fructose metabolism
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by interaction with ZNF224
    ASSOCIATED DISORDERS
    corresponding disease(s) ALDOA
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in most cancers of lung
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS