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FLASH GENE
Symbol ALDH1B1 contributors: mct - updated : 08-10-2011
HGNC name aldehyde dehydrogenase 1 family, member B1
HGNC id 407
Location 9p13.1      Physical location : 38.392.701 - 38.398.655
Synonym name
  • acetaldehyde dehydrogenase 5
  • mitochondrial aldehyde dehydrogenase X
  • Synonym symbol(s) ALDH5, ALDHX, MGC2230
    EC.number 1.2.1.3
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text intronless in the coding region
    STRUCTURE 5.96 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    MRPS21P4 9p13.1 mitochondrial ribosomal protein S21 pseudogene 4 MELK 9p11.2 maternal embryonic leucine zipper kinase PAX5 9p13 paired box gene 5 (B-cell lineage specific activator protein) LOC389720 9 LOC389720 LOC392315 9 similar to 60S ribosomal protein L32 FLJ22611 GRHPR 9q11.2-q12 glyoxylate reductase/hydroxypyruvate reductase ZBTB5 9p13.1 zinc finger and BTB domain containing 5 LOC158237 9p13.1 similar to potassium channel tetramerisation domain containing 9 PAF53 9p13.1 RNA polymerase I associated factor 53 FBXO10 9p12 F-box only protein 10 LOC389721 9 similar to RAB1B, member RAS oncogene family; small GTP-binding protein FRMPD1 9p13.1 FERM and PDZ domain containing 1 FLJ31455 9p13.1 hypothetical protein FLJ31455 RRP40 9p11 exosome component Rrp40 MRPS10P5 9p12 exosome component Rrp40 MGC10765 9p13.1 hypothetical protein MGC10765 MCART1 9p13.3-p12 mitochondrial carrier triple repeat 1 SHB 9p12-p11 SHB (Src homology 2 domain containing) adaptor protein B ALDH1B1 9p13 aldehyde dehydrogenase 1 family, member B1 LOC347252 9p12 similar to bA113O24.1 (similar to insulin-like growth factor binding protein) LOC340501 9p12 similar to transcription elongation factor IIS - mouse LOC340502 9p12 similar to GAS2-related protein isoform beta FLJ35740 9p12 FLJ35740 protein LOC392316 9 similar to SNAG1 CASPR3 9p12 cell recognition molecule CASPR3 LOC392317 9 similar to SPF45 protein LOC389722 9 similar to cell recognition molecule CASPR3 isoform 1 LOC389723 9 similar to chromosome 9 open reading frame 36 LOC392318 9 similar to 6-pyruvoyl-tetrahydropterin synthase DKFZP572C163 9p12 DKFZP572C163 protein LOC389724 9 similar to FK506-binding protein 4 (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase) (p59 protein) (HSP binding immunophilin) (HBI) (FKBP52 protein) (52 kDa FK506 binding protein) (FKBP59) LOC392319 9 similar to ATP synthase alpha chain, mitochondrial precursor LOC389725 9 similar to cell recognition molecule CASPR3 isoform 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 3088 - 517 - 1998 9490025
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly Homo sapiens
     intestinelarge intestinecolon moderately Homo sapiens
     liver   highly Homo sapiens
    Endocrinepancreas   highly Homo sapiens
     thyroid   highly
    Respiratorylung   moderately Homo sapiens
    Skin/Tegumentskin   highly
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 19-AA mitochondrial signal sequence at its N-terminus
  • mono polymer homomer , tetramer
    HOMOLOGY
    intraspecies homolog to ALDH1A1
    Homologene
    FAMILY aldehyde dehydrogenase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,nucleus
    basic FUNCTION
  • catalizing the propionaldehyde
  • catalyze the oxidation of endogenous and exogenous aldehydes to their corresponding acids
  • play a major role in the detoxification of alcohol-derived acetaldehyde
  • mitochondrial ALDH that metabolizes a wide range of aldehyde substrates including acetaldehyde and products of lipid peroxidation (LPO)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    dramatically upregulated in human colonic adenocarcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker potential biomarker for human colon cancer
    Therapy target
    ANIMAL & CELL MODELS