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FLASH GENE
Symbol AKT3 contributors: mct - updated : 29-11-2014
HGNC name v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
HGNC id 393
Corresponding disease
DEL1Q44 chromosome 1q44 microdeletion syndrome
MPPH2 megalencephaly-polymicrogyria-polydactyly-hydrocephalus 2
Location 1q44      Physical location : 243.651.534 - 244.006.553
Synonym name
  • protein kinase B gamma
  • RAC-gamma serine/threonine-protein kinase
  • Synonym symbol(s) RACPKG, PKBG, PRKBG
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 355.35 kb     14 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    CHRM3 1q41-q44 cholinergic receptor, muscarinic 3 LOC128136 1q43 similar to Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMG-CoA synthase) (3-hydroxy-3-methylglutaryl coenzyme A synthase) LOC284711 1q43 similar to 40S ribosomal protein S7 (S8) FMN2 1q43 formin 2 LOC266783 1q43 proteasome 26S non-ATPase subunit 2 pseudogene FLJ21195 1q43 protein related to DAN and cerberus LOC391180 1 similar to 40S ribosomal protein S11 RGS7 1q43 regulator of G-protein signalling 7 LOC388755 1 LOC388755 FH 1q42.1 fumarate hydratase KMO 1q42-q44 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) OPN3 1q43 opsin 3 (encephalopsin, panopsin) CHML 1q32-q41 choroideremia-like (Rab escort protein 2) FLJ32978 1q43 hypothetical protein FLJ32978 LOC391181 1 similar to 60S ribosomal protein L6 (TAX-responsive enhancer element binding protein 107) (TAXREB107) (Neoplasm-related protein C140) EXO1 1q43 exonuclease 1 LOC391182 1 similar to 60S ribosomal protein L23a FLJ40773 1q43 hypothetical protein FLJ40773 LOC391183 1 similar to ribosomal protein L24-like; 60S ribosomal protein L30 isolog; my024 protein; homolog of yeast ribosomal like protein 24 LOC391184 1 similar to RCC1-like LOC343365 1q43 similar to capicua homolog LOC388756 1 similar to hypothetical protein LOC349114 LOC388757 1 LOC388757 LOC339077 1q43 hypothetical gene supported by AK092558; AL137655; BC006361 KAB 1q44 KARP-1-binding protein SDCCAG8 1q44 serologically defined colon cancer antigen 8 AKT3 1q43-q44 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) LOC388758 1 LOC388758 LOC339529 1q44 hypothetical protein LOC339529 ZNF238 1q44-qter zinc finger protein 238 LOC343484 1q44 hypothetical LOC343484 LOC200159 1q44 hypothetical LOC200159 LOC126826 1q44 similar to TGFB-induced factor 2; TGF(beta)-induced transcription factor 2; transcription growth factor-beta-induced factor 2; homeobox protein TGIF2; 5-TG-3 interacting factor 2 ADSS 1cen-q12 adenylosuccinate synthase MGC33370 1q44 hypothetical protein MGC33370 HCP5 6p21.3 HLA complex P5 PNAS-4 1q44 CGI-146 protein LOC116228 1q44 hypothetical protein LOC116228 HNRPU 1q44 heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) MGC12458 1q44 hypothetical protein MGC12458 MGC35030 1q44 hypothetical protein MGC35030 FLJ10157 1q44 hypothetical protein FLJ10157 SMYD3 1q44 SET and MYND domain containing 3 LOC255654 1q44 hypothetical protein LOC255654 TFB2M 1q44 transcription factor B2, mitochondrial FLJ32001 1q44 hypothetical protein FLJ32001 CGI-49 1q44 CGI-49 protein LOC391185 1 similar to kinesin-like protein (103.5 kD) (klp-6) ELYS 1q44 ELYS transcription factor-like protein TMBS62
    RNA
    TRANSCRIPTS type messenger
    text pkb gamma and pkb gamma 1
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 7091 55.8 479 - Cristiano
    17 - 1584 - 465 - Cristiano
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Digestiveliver   lowly
    Nervousbrain   highly
    Reproductivemale systemtestis  lowly
    Respiratorylung   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text highly in heart, liver, brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a SH2 and a pleckstrin (PH) homology N terminal domain
  • a short alpha helical linker
  • a C terminal kinase domain
  • HOMOLOGY
    interspecies homolog to V-akt murine thymoma viral oncogene 3
    homolog to C.elegans F28H6.1
    Homologene
    FAMILY
  • Ser/Thr protein kinase, B family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    intracellular,nuclear envelope
    text
  • localized in both the nucleus and nuclear membrane
  • basic FUNCTION
  • AKT is a key regulator for cell growth, cell survival and metabolic insulin action
  • involved in the regulation of diverse cellular functions such as cell proliferation, energy metabolism, and apoptosis
  • AKT2 and AKT3 play an important role in the viability of human malignant glioma cells
  • may oppose AKT1 in lung tumorigenesis and lung tumor progression
  • AKT1 and AKT3 are essential for the proliferation of reprogrammed cells
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    text survival of lymphoid and other cell types
    PATHWAY
    metabolism
    signaling
  • central role of PI3K/AKT signaling in vascular, limb and brain development
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • enhanced AKT2 or AKT3 activation also promotes reprogramming and coordinates with LIF to activate STAT3
  • AKT3 is likely a regulator of mitochondrial dynamics in the vasculature via regulation of XPO1-dependent nuclear export
  • cell & other
    REGULATION
    activated by growth factors via PI3K (phosphatidyl inositol 3-kinase) binding to PH domain in the antiapoptotic PI3K pathway induced by insulin growth factor 1, and maybe other
    coactivated by TCL1
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL1Q44 , MPPH2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in estrogen receptor-negative breast tumor
    tumoral       gain of function
    associated with the survival of melanoma cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene for microcephaly and corpus callosum agenesis in 1qter microdeletion syndrome
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbrainglioma/neuroblstoma
    targeting AKT2 and AKT3 may hold promise for the treatment of patients with gliomas (PMID: 20167810)
    ANIMAL & CELL MODELS