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FLASH GENE

Symbol

AKR7A3

contributors: mct - updated : 03-09-2008

HGNC name	aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
HGNC id	390

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p35.1-p36.23      Physical location : 19.609.056 - 19.615.280
Synonym name	aflatoxin B1 aldehyde reductase member 3
	aflatoxin B1 aldehyde reductase 2
Synonym symbol(s)	AFB1-AR 2 , AFAR2
EC.number	1.-.-.-

DNA

TYPE	functioning gene
STRUCTURE	6.00 kb     7 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed AKR7A3 7 - 1301 37 331 - Gregory (2006)

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine           stomach         Endocrine pancreas         Urinary kidney

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

aldo/keto reductase 2 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol
	May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

drug

signaling

a component

INTERACTION

DNA

RNA

small molecule	cofactor, nucleotide,
	NADPH

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS