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FLASH GENE
Symbol AKR7A3 contributors: mct - updated : 03-09-2008
HGNC name aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
HGNC id 390
Location 1p35.1-p36.23      Physical location : 19.609.056 - 19.615.280
Synonym name
  • aflatoxin B1 aldehyde reductase member 3
  • aflatoxin B1 aldehyde reductase 2
  • Synonym symbol(s) AFB1-AR 2 , AFAR2
    EC.number 1.-.-.-
    DNA
    TYPE functioning gene
    STRUCTURE 6.00 kb     7 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1301 37 331 - Gregory (2006)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine    
     stomach    
    Endocrinepancreas    
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • aldo/keto reductase 2 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol
  • May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism drug
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • NADPH
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS