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FLASH GENE
Symbol AKR7A2 contributors: - updated : 26-04-2005
HGNC name aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
HGNC id 389
Location 1p36.1-p35      Physical location : 19.630.458 - 19.638.640
Synonym name aflatoxin B1 aldehyde reductase
Synonym symbol(s) AFAR, AKR7
DNA
TYPE functioning gene
STRUCTURE 8.00 kb     7 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map pter - D1S436 - D1S2647 - AKR7A2 - D1S199 - PLA2G2A - D1S2843 - cen
Authors Praml (98)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Cardiovascularheart    
Digestiveliver    
 stomach    
Endocrinepancreas    
Nervousbrain    
Reproductivemale systemprostate   
 male systemtestis   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
Muscularstriatumskeletal  
cell lineage
cell lines renal carcinoma cells
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus norvegicus gene
Homologene
FAMILY aldo/keto reductase 2 family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • aldo-ketoreductase,(especially aflatoxin B1-aldehyde reductase), catalyzing the reduction of 2-carboxybenzaldehyde (2-CBA) and related molecules
  • involved in endogenous detoxication pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism drug , lipid/lipoprotein
    signaling
    detoxication
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    NADPH
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS