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FLASH GENE
Symbol AKR7A2 contributors: - updated : 26-04-2005
HGNC name aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
HGNC id 389
Location 1p36.1-p35      Physical location : 19.630.458 - 19.638.640
Synonym name aflatoxin B1 aldehyde reductase
Synonym symbol(s) AFAR, AKR7
DNA
TYPE functioning gene
STRUCTURE 8.00 kb     7 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map pter - D1S436 - D1S2647 - AKR7A2 - D1S199 - PLA2G2A - D1S2843 - cen
Authors Praml (98)
Physical map
MGC15730 1p36.13 hypothetical protein MGC15730 FLJ38753 1p36.13 hypothetical protein FLJ38753 LOC391012 1 similar to Putative dynein light chain protein DJ8B22.1 PAX7 1p36.2-p36.12 paired box gene 7 TAS1R2 1p36.13 taste receptor, type 1, member 2 ALDH4A1 1p36 aldehyde dehydrogenase 4 family, member A1 RBAF600 1p36.13 retinoblastoma-associated factor 600 KIAA0090 1p36.13 retinoblastoma-associated factor 600 C1orf33 1p36.13 chromosome 1 open reading frame 33 AFAR3  aflatoxin B1 aldehyde reductase 3 AKR7A3 1p35.1-p36.23 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) AKR7A2 1p36.1-p35 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) FLJ20320 CAPZB 1p36.1 capping protein (actin filament) muscle Z-line, beta LOC388600 1 similar to protein of fungal metazoan origin like (11.1 kD) (2C514) NBL1 1p36.13-p36.11 neuroblastoma, suppression of tumorigenicity 1 HTR6 1p36-p35 5-hydroxytryptamine (serotonin) receptor 6 LOC255104 1p36.13 hypothetical protein LOC255104 FLJ20225 1p36.13 hypothetical protein FLJ20225 LOC254897 1p36.13 similar to OSJNBa0043A12.32 PLA2G2E 1p36.13 similar to OSJNBa0043A12.32 PLA2G2A 1p36.1-p35 phospholipase A2, group IIA (platelets, synovial fluid) PLA2G5 1p36-p34 phospholipase A2, group V PLA2G2D 1p36.12 phospholipase A2, group IID PLA2G2F 1p35 phospholipase A2, group IID LOC391013 1 similar to Group IIC secretory phospholipase A2 precursor (Phosphatidylcholine 2-acylhydrolase GIIC) (GIIC sPLA2) (PLA2-8) (14 kDa phospholipase A2) FLJ25429 FLJ32784 1p36.13 hypothetical protein FLJ32784 LOC388601 1 LOC388601 CaMKIINalpha 1p36.13 calcium/calmodulin-dependent protein kinase II FLJ12875 1p36.13 hypothetical protein FLJ12875 LOC163933 1p36.12 similar to cDNA sequence BC022623 CDA 1p36.2-p35 cytidine deaminase
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Cardiovascularheart    
Digestiveliver    
 stomach    
Endocrinepancreas    
Nervousbrain    
Reproductivemale systemprostate   
 male systemtestis   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
Muscularstriatumskeletal  
cell lineage
cell lines renal carcinoma cells
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus norvegicus gene
Homologene
FAMILY aldo/keto reductase 2 family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • aldo-ketoreductase,(especially aflatoxin B1-aldehyde reductase), catalyzing the reduction of 2-carboxybenzaldehyde (2-CBA) and related molecules
  • involved in endogenous detoxication pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism drug , lipid/lipoprotein
    signaling
    detoxication
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    NADPH
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS