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FLASH GENE
Symbol AKR1C3 contributors: mct - updated : 16-10-2018
HGNC name aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
HGNC id 386
Location 10p15.1      Physical location : 5.136.567 - 5.149.876
Synonym name
  • dihydrodiol dehydrogenase 3
  • dihydrodiol dehydrogenase X
  • hydroxysteroid (17-beta) dehydrogenase 5
  • Synonym symbol(s) KIAA0119, DD3, HAKRB, HSD17B5, DDH1, HA1753, HAKRe, PGFS
    EC.number 1.3.1.20, 1.1.1.188, 1.1.1.1213, 1.1.1.63, 1.1.1.6
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 13.31 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    text structure a KLF15 binding site in the promoter (Du 2009)
    MAPPING cloned Y linked N status provisional
    Map pter - D10S591 - D10S552 - AKR1C3 - AKR1C4 - D10S1713 - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1224 36.7 323 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis    Homo sapiens
     male systemprostate    Homo sapiens
    Urinarybladder     Homo sapiens
     kidney     Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • aldoketo-reductase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • aldo-ketoreductase (3-alpha hydroxysteroid dehydrogenase, type II)
  • catalyzing the detoxication of polycyclic aromatic hydrocarbons
  • inactivates circulating steroid hormones and is involved in polycyclic aromatic hydrocarbon (PAH) carcinogenesis
  • its multispecificity is important for steroid metabolism in gonadal and peripheral tissues, and is a consequence of the architecture of its binding and catalytic sites
  • implicated in regulating ligand access to the androgen receptor, estrogen receptor, and peroxisome proliferator activating receptor gamma in hormone target tissues
  • functional prostaglandin F synthase and a negative modulator of the availability of ligands for the nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARgamma)
  • mediator of carcinogen-induced initiation of leukemia, and novel regulator of erythroid differentiation
  • AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis
  • new role for AKR1C3 in regulating SIAH2 stability and thus enhancing SIAH2-dependent regulation of AR activity in prostate cancer cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism drug , lipid/lipoprotein , other
    signaling
    prostaglandins
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with KLF15 (transcriptional regulator of AKR1C3)
  • cell & other
    REGULATION
    inhibited by in adipose tissue significantly reduced in response to dietinduced weight loss and correlate with leptin levels
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to bladder cancer risk
    Variant & Polymorphism other genetic variation could be associated with bladder cancer risk
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS