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FLASH GENE
Symbol AKR1C2 contributors: mct - updated : 16-10-2018
HGNC name aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
HGNC id 385
Corresponding disease
SRXY8 46XY sex reversal 8
Location 10p15.1      Physical location : 5.031.965 - 5.060.207
Synonym name
  • bile acid binding protein
  • dihydrodiol dehydrogenase 2
  • pseudo-chlordecone reductase
  • type II dihydrodiol dehydrogenase
  • Synonym symbol(s) DDH2, HAKRD, DD2, BABP, MCDR2, AKR1C-pseudo, DD, DD-2, DD/BABP, HBAB, SRXY8, TDD
    EC.number 1.3.1.20/1.1.1.357
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 30.26 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    LOC389931 10 LOC389931 PFKP 10p15 phosphofructokinase, platelet PITRM1 10p15.2 pitrilysin metalloproteinase 1 LOC387631 10 LOC387631 COPEB 10p15 core promoter element binding protein LOC387632 10 LOC387632 AKR1CL2 10p15.2 aldo-keto reductase family 1, member C-like 2 LOC389932 10 similar to 3-hydroxyhexobarbital dehydrogenase 1/3-alpha, 17-beta-hydroxysteroid dehydrogenase AKR1C1 10p15-p14 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) AKR1C2 10p15-p14 aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III) AKR1C3 10p15-p14 aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) LOC389933 10 similar to 3(20)alpha-hydroxysteroid/dihydrodiol dehydrogenase LOC340811 10p15.2 protein RAKc AKR1C4 10p15-p14 aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4) LOC389934 10 similar to protein RAKc UCN3 10p15.1 urocortin 3 (stresscopin) FLJ21665 10p15.1 hypothetical protein FLJ21665 NET1 10p15 neuroepithelial cell transforming gene 1 CALML5 10p15.1 calmodulin-like 5 CALML3 10pter-p13 calmodulin-like 3 ASB13 10p15.1 ankyrin repeat and SOCS box-containing 13 FLJ20360 10p15.1 hypothetical protein FLJ20360 GDI2 10p15 GDP dissociation inhibitor 2 ANKRD16 10p15.1 ankyrin repeat domain 16 FBXO18 10p15.1 F-box only protein, helicase, 18 IL15RA 10p15-p14 interleukin 15 receptor, alpha IL2RA 10p15-p14 interleukin 2 receptor, alpha SPF45 LOC387633 10 LOC387633 LOC142937 10p15.1 hypothetical protein BC008131 PFKFB3 10p15-p14 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 PRKCQ 10p15 protein kinase C, theta
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 3521 - 323 - 2018 29369461
    11 - 3621 - 323 - 2018 29369461
    8 - 3309 - 297 - 2018 29369461
    4 - 1098 - 139 - 2018 29369461
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Nervousbrain   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY aldoketo-reductase family
    CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • aldo-ketoreductas (3-alpha hydroxysteroid dehydrogenase, type III), catalyzing the detoxification of polycyclic aromatic hydrocarbons
  • AKR1C1, AKR1C2 subfamily genes are stress-inducible and might function as survival factors in keratinocytes
  • AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis
  • AKR1C2, AKR1C4, are involved in the metabolism of steroids and other carbonyl compounds including drugs
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text bile acid
    PATHWAY
    metabolism drug , lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cytosolic enzyme that has an important role in the deactivation of the potent androgen dihydrotestosterone (DHT)
  • a major proinflammatory cytokine, IL1B, can facilitate local progesterone metabolism in a cell type critical for maintaining uterine cervical structure via regulating expression of AKR1C1 and AKR1C2
  • interplay between glucocorticoids and AKR1C2-dependent androgen inactivation may locally modulate adipogenesis and lipid accumulation in a depot-specific manner
  • AKR1C2 (positive factor) and NF1 (negative factor), are the MTDH downstream players in the process of metastasis in liver cancer
  • cell & other
    REGULATION
    inhibited by long-chain fatty acids that inhibit AKR1C1, AKR1C2, AKR1C4
    ASSOCIATED DISORDERS
    corresponding disease(s) SRXY8
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    is associated with disease progression in prostatic cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • AKR1C2 could be a tumor marker for urinary bladder cancer (UBC)
  • Therapy target
    ANIMAL & CELL MODELS