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FLASH GENE
Symbol AKR1C1 contributors: mct - updated : 16-10-2018
HGNC name aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
HGNC id 384
Location 10p15.1      Physical location : 5.005.453 - 5.020.157
Synonym name
  • dihydrodiol dehydrogenase 1
  • 20-alpha (3-alpha)-hydroxysteroid dehydrogenase
  • dihydrodiol dehydrogenase isoform DD1
  • hepatic dihydrodiol dehydrogenase
  • Synonym symbol(s) DDH, HBAB, DDH1, HAKRC, DD1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1/DD2, H-37, MBAB
    EC.number 1.3.1.20/ 1.1.1.149
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 16.71 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC389931 10 LOC389931 PFKP 10p15 phosphofructokinase, platelet PITRM1 10p15.2 pitrilysin metalloproteinase 1 LOC387631 10 LOC387631 COPEB 10p15 core promoter element binding protein LOC387632 10 LOC387632 AKR1CL2 10p15.2 aldo-keto reductase family 1, member C-like 2 LOC389932 10 similar to 3-hydroxyhexobarbital dehydrogenase 1/3-alpha, 17-beta-hydroxysteroid dehydrogenase AKR1C1 10p15-p14 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) AKR1C2 10p15-p14 aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III) AKR1C3 10p15-p14 aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) LOC389933 10 similar to 3(20)alpha-hydroxysteroid/dihydrodiol dehydrogenase LOC340811 10p15.2 protein RAKc AKR1C4 10p15-p14 aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4) LOC389934 10 similar to protein RAKc UCN3 10p15.1 urocortin 3 (stresscopin) FLJ21665 10p15.1 hypothetical protein FLJ21665 NET1 10p15 neuroepithelial cell transforming gene 1 CALML5 10p15.1 calmodulin-like 5 CALML3 10pter-p13 calmodulin-like 3 ASB13 10p15.1 ankyrin repeat and SOCS box-containing 13 FLJ20360 10p15.1 hypothetical protein FLJ20360 GDI2 10p15 GDP dissociation inhibitor 2 ANKRD16 10p15.1 ankyrin repeat domain 16 FBXO18 10p15.1 F-box only protein, helicase, 18 IL15RA 10p15-p14 interleukin 15 receptor, alpha IL2RA 10p15-p14 interleukin 2 receptor, alpha SPF45 LOC387633 10 LOC387633 LOC142937 10p15.1 hypothetical protein BC008131 PFKFB3 10p15-p14 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 PRKCQ 10p15 protein kinase C, theta
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1384 - 323 - 1995 7626489
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Nervousbrain   highly
    Reproductivemale systemtestis   
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY aldoketo-reductase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • aldo-ketoreductase, catalyzing detoxification of polycyclic aromatic hydrocarbons
  • AKR1C1, AKR1C2 subfamily genes are stress-inducible and might function as survival factors in keratinocytes
  • AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis
  • crucial role of AKR1C1 in regulating both metastasis and drug resistance
  • not only plays an important role in hormone metabolism but is believed to be involved in carcinogen metabolism
  • plays an important role in the development and progression of Small-cell lung cancer (SCLC)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • a major proinflammatory cytokine, IL1B, can facilitate local progesterone metabolism in a cell type critical for maintaining uterine cervical structure via regulating expression of AKR1C1 and AKR1C2
  • cell & other
    REGULATION
    inhibited by long-chain fatty acids that inhibit AKR1C1, AKR1C2, AKR1C4
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    are responsible for sexual development dysgenesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may represent an independent biomarker for assessment of the primary prognosis and therapy of small-cell lung cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancermetastases 
    should be a potent molecular target in invasive bladder cancer treatment
    ANIMAL & CELL MODELS