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FLASH GENE
Symbol AKR1B10 contributors: mct/pgu - updated : 18-02-2012
HGNC name aldo-keto reductase family 1, member B10 (aldose reductase)
HGNC id 382
Location 7q33      Physical location : 134.212.343 - 134.226.165
Synonym name
  • aldo-keto reductase family 1, member B11 (aldose reductase-like)
  • aldose reductase-like 1
  • small intestine reductase
  • aldose reductase-related protein
  • aldose reductase-like peptide
  • SI reductase
  • Synonym symbol(s) AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI, MGC14103
    EC.number 1.1.1.2
    DNA
    TYPE functioning gene
    STRUCTURE 13.76 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site
    text structure
  • a TATA-like and a CAAT box (-145 to -140bp and -193 to -190bp upstream the transcriptional start site),
  • binding sites for oncogenic and tumor suppressor proteins like c-Ets, C/EBP, AP-1 and TP53
  • MAPPING cloned Y linked N status provisional
    Physical map
    DKFZp434G0625 7q32.3 hypothetical protein DKFZp434G0625 FLJ40288 7q32.3 hypothetical protein FLJ40288 FLJ20420 FAM10A7 11p15-p14 family with sequence similarity 10, member A7 SEC8 FLJ32786 7q33 hypothetical protein FLJ32786 SLC35B4 7q33 solute carrier family 35, member B4 AKR1B1 7q25 aldo-keto reductase family 1, member B1 (aldose reductase) AKR1B10 7q33 aldo-keto reductase family 1, member B10 (aldose reductase) LOC392097 7 similar to aldo-keto reductase family 1, member B10; aldose reductase-like 1; aldo-keto reductase family 1, member B11 (aldose reductase-like); aldose reductase-like peptide; aldose reductase-related protein; small intestine reducta BPGM 7q32 2,3-bisphosphoglycerate mutase LOC392098 7 similar to beta-tubulin CALD1 7q33-q34 caldesmon 1 LOC340351 7q33 hypothetical protein LOC340351 LOC346671 7q33 pseudogene of RING finger protein 14 FLJ11000 7q33 hypothetical protein FLJ11000 MGC5242 7q33 hypothetical protein MGC5242 KIAA1466 7q33 KIAA1466 protein HSPC049 7q33 HSPC049 protein LOC346673 7q33 STRA8 LOC346674 7q33 similar to Na+/L-ascorbic acid transporter 1; SVCT1 CNOT4 7q33 CCR4-NOT transcription complex, subunit 4 LOC392099 7 hypothetical gene supported by AK075360; NM_003002 NUP205 7q33 nucleoporin 205kDa LOC136321 7q33 similar to 60S ribosomal protein L15 SLC13A4 7q33 solute carrier family 13 (sodium/sulfate symporters), member 4 LOC389558 7 similar to HWKM1940 MTPN 7q33-q35 myotrophin
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1610 35.8 316 - 1998 9565553
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus    
    Digestiveintestinesmall intestine  highly Homo sapiens
     intestinelarge intestinecolon highly Homo sapiens
     liver    
    Endocrineadrenal gland   highly
    Reproductivemale systemprostate   
     male systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to rattus Akr1b10 (82.6pc)
    Homologene
    FAMILY
  • aldo-keto reductase superfamily
  • CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • aldo-ketoreductase reducing aromatic and aliphatic aldehydes, less active on hexoses
  • playing a critical role in the growth and proliferation of cancer cells by detoxifying reactive carbonyls and regulating fatty acid biosynthesis
  • may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs
  • may regulate cell proliferation and cellular response to additional carbonyl stress
  • regulates the stability of acetyl-coA carboxylase-alpha and is a novel regulator of the biosynthesis of fatty acid in breast cancer cells
  • may play a greater role in lung carcinogenesis through dysregulation of reinoic acid homeostasis than through oxidation of PAH trans-dihydrodiols
  • dysregulated in Barrett's esophagus and esophageal adenocarcinoma
  • might be useful as a new marker for identification of high lung cancer risk patients in usual interstitial pneumonia
  • may play an important role in tumor progression or drug resistance
  • new secretory protein belonging to a lysosome-mediated non-classical protein-secretion pathway and is a potential serum marker
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NFE2L2 is one of the major factors involved in the AKR1B10 gene regulation
  • selective target for modification and inhibition by prostaglandin A(1)
  • cell & other
    REGULATION
    Other regulated by NFE2L2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinoma, lung squamous carcinoma and lung adenocarcinoma in smokers
    tumoral     --over  
    high expression of AKR1B10 reflects a less aggressive tumour behaviour, in hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS