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FLASH GENE
Symbol AKR1A1 contributors: - updated : 07-05-2007
HGNC name aldo-keto reductase family 1, member A1 (aldehyde reductase)
HGNC id 380
Location 1p33-p32      Physical location : 46.016.497 - 46.035.720
Synonym name
  • alcohol dehydrogenase
  • aldehyde reductase
  • Synonym symbol(s) ALR, ALDR1, MGC12529, MGC1380
    EC.number 1.1.1.2
    DNA
    TYPE functioning gene
    STRUCTURE 19.00 kb     10 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   enhancer   transcription factor
    text structure DDIT3 binding site (in competition with ZNF143)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text two alternatively spliced transcripts encoding the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 1437 36 324 ubiquitous Barski, Bohren
    lacking exon 1a
    - splicing 1556 - 325 ubiquitous Barski, Bohren
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
     liver   highly
    Endocrinethyroid   highly
    Nervousbrainforebraincerebral cortex highly
    Urinarykidney   predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to murine Akr1a4
    Homologene
    FAMILY aldo-keto reductase (AKR) superfamily
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • aldehyde (aldoketo) reductase 1, monomeric, NADPH dependent, reducing various biogenic and xenobiotic aldehyde compounds
  • playing an important role in detoxification of arising reactive metabolites during cell proliferation and tissues development
  • NADPH-dependent oxidoreductase involved in catalyzing the reduction of aldehydes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    NADPH
    protein binding ZNF143 or DDIT3
    cell & other
    REGULATION
    Other regulated by ZNF143 and DDIT3
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to non-Hodgkin lymphoma (NHL)
    Variant & Polymorphism SNP significantly associated with an increased overall risk of NHL
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS