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FLASH GENE
Symbol AKIRIN2 contributors: mct - updated : 27-01-2015
HGNC name akirin 2
HGNC id 21407
Location 6q15      Physical location : 88.384.578 - 88.411.985
Synonym name
  • chromosome 6 open reading frame 166
  • fourteen-three-three beta interactant 1
  • Synonym symbol(s) FLJ10342, dJ486L4.2, C6orf166, FBI1
    DNA
    TYPE functioning gene
    STRUCTURE 27.41 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1948 - 203 - 2008 18066067
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart     Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticplasma    Homo sapiens
    cell lineage
    cell lines strong expression in several tumor cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • akirin family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • conserved nuclear factor required for innate immune responses
  • promotes sustained ERK1/2 activation through repression of MAKP1 transcription, resulting in promotion of tumorigenicity and metastasis
  • plays an important role in oncogenesis of LLC1 lung carcinoma cells, an may also serve as an oncogene in other cancers
  • important nuclear factor which plays functions in innate immune response, myogenesis, muscle development, and carcinogenesis
  • nuclear protein, bridging NFKB1 and the chromatin remodeling SWI/SNF complex by interacting with SMARCD proteins as well as NFKBIZ, which forms a complex with the NFKB1 p50 subunit
  • is critical for inducing inflammatory genes by bridging NFKBIZ and the SWI/SNF complex
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • AKIRIN2-YWHAB complex could act as a transcriptional silencer, and MAPK1 was one of the target genes of the AKIRIN2-YWHAB complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • YWHAB-binding factor
  • BCAM is a suppressive oncoprotein, and FBI1/AKIRIN2 is involved in tumorigenicity and metastasis of hepatoma through the downregulation of suppressive oncogenes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    inhibited tumorigenicity and metastasis accompanying a decrease in MMP9 (matrix metalloproteinase-9) expression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS