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FLASH GENE
Symbol AKAP8 contributors: mct - updated : 02-01-2017
HGNC name a kinase (PRKA) anchor protein 8
HGNC id 378
Location 19p13.1-q12      Physical location : 15.464.340 - 15.490.603
Synonym name
  • A-kinase anchor protein 95 kDa
  • weakly similar to A-kinase anchor protein 95, AKAP95 [R.norvegicus]
  • Synonym symbol(s) AKAP95, DKFZp586B1222
    DNA
    TYPE functioning gene
    STRUCTURE 26.00 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 3545 76 692 - Olsen (2006)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Endocrinepancreas   highly
     thyroid   highly
    Nervousbrainhindbraincerebellum  
     nerve   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Connectivebone  highly
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
     digestive
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an amphipathic helix binding domain
  • HOMOLOGY
    interspecies homolog to rattus Akap95
    Homologene
    FAMILY
  • AKAP95 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text in the nucleus during interphase and is distinctly redistributed during mitosis
    basic FUNCTION
  • a kinase (PRKA regulatory subunit RIIA) anchor protein tethering the enzyme near its physiological substrate
  • having a cell cycle-dependent interaction with the RII subunit of PKA
  • involved in the process of apoptotic nuclear morphological changes
  • potential carrier protein for active caspase 3 from the cytoplasm into the nuclei in apoptotic cells
  • regulation of transcription by the KMT2B complex and MLL complex-associated AKAP8
  • involvement of AKAP8 in proper spindle assembly checkpoint (SAC) function likely through its interaction with TPR
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • caspase 3-binding protein
  • partner for D-type cyclins
  • TPR is a novel AKAP8 binding partner
  • cell & other
    REGULATION
    Other maybe cell cycle dependent
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS