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FLASH GENE
Symbol AKAP7 contributors: mct - updated : 20-11-2013
HGNC name a kinase (PRKA) anchor protein 7
HGNC id 377
Location 6q23.2      Physical location : 131.466.460 - 131.604.673
Synonym name
  • A-kinase anchor protein 9 kDa
  • A-kinase anchor protein, 18-kD
  • A-kinase anchoring protein 18
  • Synonym symbol(s) AKAP18, AKAP15
    DNA
    TYPE anonymous DNA segment
    STRUCTURE 138.20 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D6S407 - D6S1620 - AKAP7 - D6S262 - qter
    Authors Gene Map (98)
    Physical map
    ARHGAP18 6q23.1 Rho GTPase activating protein 18 C6orf191 6q23.1 chromosome 6 open reading frame 191 L3MBTL3 6q23 l(3)mbt-like 3 (Drosophila) SAMD3 6q23.1 sterile alpha motif domain containing 3 KIAA1913 6q23.1 KIAA1913 EPB41L2 6q23 erythrocyte membrane protein band 4.1-like 2 AKAP7 6q22-q23 a kinase (PRKA) anchor protein 7 ARG1 6q22.3-q23.1 arginase, liver CRSP3 6q22.33-q24.1 cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa ENPP3 6q22 ectonucleotide pyrophosphatase/phosphodiesterase 3 OR2A4 6q33-q35 olfactory receptor, family 2, subfamily A, member 4 ENPP1 6q22-q23 ectonucleotide pyrophosphatase/phosphodiesterase 1 CTGF 6q23.1 connective tissue growth factor MOXD1 6q22-q23 monooxygenase, DBH-like 1 STX7 6q22.3-q24 syntaxin 7 TAR3 6q23.1 trace amine receptor 3 GPR102 6q23.2 G protein-coupled receptor 102 TA4 6q23.1 trace amine receptor 4 PNR 6q23 putative neurotransmitter receptor GPR57 6q23-q24 G protein-coupled receptor 57 GPR58 6q23-q24 G protein-coupled receptor 58 TAR1 6q23.1 trace amine receptor 1 VNN1 6q23-q24 vanin 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2279 - 81 glucose and GH stimulate expression of AKAP7 alpha whereas palmitate reduces its expression (Josefsen 2010) 2011 21149637
  • isoform alpha
  • targets PKA to the lateral plasma membrane and facilitates the functional coupling of PKA to L-type calcium channels
  • 3 - 2348 - 104 - 2011 21149637
  • isoform beta
  • an extra 23-amino acid segment in the N-terminal region compared to isoform alpha, involved in the targeting of PKA to the apical plasma membrane
  • 7 - 2821 - 326 . glucose inhibits AKAP7 gamma mRNA expression (Josefsen 2010) . oocytes 2011 21149637
  • isoform gamma
  • targets PKA to the cytoplasm
  • responsible for regulating PKA-mediated gene transcription in both somatic cells and oocytes
  • - - - - - in the kidney, mainly expressed in principal cells of the inner medullary collecting duct 2011 21149637
  • identified on the same intracellular vesicles as AQP2 and PKA
  • may be involved in the AQP2 shuttle
  • may act as a scaffold that coordinates PKA phosphorylation of PLN and the adrenergic effect on Ca2+ re-uptake
  • EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrineadrenal gland   highly
    Nervousbrain   highly
     nerve   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a central domain that may act as a phosphoesterase, binding AMP
  • secondary structure an amphipathic helix binding domain
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text in both the nucleus and cytoplasm of oocytes
    basic FUNCTION
  • A kinase (PRKA regulatory subunit RIIA) anchor protein tethering the enzyme near its physiological substrate
  • potentially involved in L-type calcium ion channel activation
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • AKAP7 interacts with neuronal CACNA1C via their C terminus
  • interaction between the ubiquitous enzyme PKC (protein kinase C) and the scaffolding protein AKAP7 (AKAP7 could play an integral role in dictating PKC localization and function in tissues where the two proteins are co-expressed)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS