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FLASH GENE
Symbol AKAP3 contributors: mct/npt - updated : 01-09-2008
HGNC name a kinase (PRKA) anchor protein 3
HGNC id 373
Location 12p13.3      Physical location : 4.724.676 - 4.754.343
Synonym name
  • sperm-oocyte binding protein
  • fibrous sheath protein of 95 kDa
  • fibrousheathin I
  • A-kinase anchor protein 110 kDa
  • sperm oocyte-binding protein
  • cancer/testis antigen 82
  • Synonym symbol(s) SOB1, AKAP110, FSP95, CT82, PRKA3
    DNA
    TYPE functioning gene
    STRUCTURE 29.00 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC283440 12p13.33 hypothetical LOC283440 LOC341511 12p13.33 similar to 60S ribosomal protein L23a FKBP4 12p13.33 FK506 binding protein 4, 59kDa MDS028 12p13.33 uncharacterized hematopoietic stem/progenitor cells protein MDS028 NRIP2 12p13.33 nuclear receptor interacting protein 2 FOXM1 12p13 forkhead box M1 MGC13204 12p13.33 hypothetical protein MGC13204 TULP3 12p13 tubby like protein 3 TEAD4 12p13.3-p13.2 TEA domain family member 4 LOC387825 12 similar to ribosomal protein L13a; 60S ribosomal protein L13a; 23 kD highly basic protein NET-5 12p13.33 transmembrane 4 superfamily member tetraspan NET-5 PP1057 12p13.3 hypothetical protein PP1057 LOC390280 12 similar to RIKEN cDNA 1110014F12 HRMT1L3 12p13.3 HMT1 hnRNP methyltransferase-like 3 (S. cerevisiae) MGC4266 12p13.33 hypothetical protein MGC4266 C12orf6 12p13.3 chromosome 12 open reading frame 6 LOC160382 12p13.32 similar to Heat shock cognate 71 kDa protein LOC390281 12 similar to ribosomal protein L18; 60S ribosomal protein L18 CCND2 12p13.32 cyclin D2 C12orf5 12p13.3 chromosome 12 open reading frame 5 FGF23 12p13.3 fibroblast growth factor 23 FGF6 12p13.32 fibroblast growth factor 6 C12orf4 12p13.3 chromosome 12 open reading frame 4 PIR51 12p13.2-p13.1 chromosome 12 open reading frame 4 DYRK4 12p13.3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 AKAP3 12p13 a kinase (PRKA) anchor protein 3 NDUFA9 12p13.3-p12 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa GALNT8 12p13.3 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8) KCNA6 12p13 potassium voltage-gated channel, shaker-related subfamily, member 6 KCNA1 12p13.32 potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) LOC390282 12 similar to eukaryotic translation initiation factor 3, subunit 5 (epsilon) KCNA5 12p13.32-p13.31 potassium voltage-gated channel, shaker-related subfamily, member 5 LOC387826 12 LOC387826 NTF3 12p13.31 neurotrophin 3 TMEM16B 12p13.3 transmembrane protein 16B VWF 12p13.1 von Willebrand factor CD9 12p13.31 CD9 antigen (p24) FLJ10665 12p13.32 hypothetical protein FLJ10665
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 3027 94 853 - Lea (2004)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
    Reproductivefemale systemovary   
     male systemtestis   
    Visualeye    
    cell lineage
    cell lines
    fluid/secretion sperm
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • RII binding domain
  • secondary structure an amphipathic helix binding domain
    HOMOLOGY
    Homologene
    FAMILY
  • AKAP110 family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microfilament
    basic FUNCTION
  • a kinase (PRKA regulatory subunit RIIA) anchor protein tethering the enzyme near its physiological substrate
  • may be involved in oocyte recognition
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to SPA17 in spermatozoa (binds the RII binding domain of AKAP3 along the length of the flagella)
  • cell & other
  • sperm-oocyte binding
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    correlates with poor prognosis in epithelial ovarian cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS