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FLASH GENE
Symbol AKAP3 contributors: mct/npt - updated : 01-09-2008
HGNC name a kinase (PRKA) anchor protein 3
HGNC id 373
Location 12p13.3      Physical location : 4.724.676 - 4.754.343
Synonym name
  • sperm-oocyte binding protein
  • fibrous sheath protein of 95 kDa
  • fibrousheathin I
  • A-kinase anchor protein 110 kDa
  • sperm oocyte-binding protein
  • cancer/testis antigen 82
  • Synonym symbol(s) SOB1, AKAP110, FSP95, CT82, PRKA3
    DNA
    TYPE functioning gene
    STRUCTURE 29.00 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 3027 94 853 - Lea (2004)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
    Reproductivefemale systemovary   
     male systemtestis   
    Visualeye    
    cell lineage
    cell lines
    fluid/secretion sperm
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • RII binding domain
  • secondary structure an amphipathic helix binding domain
    HOMOLOGY
    Homologene
    FAMILY
  • AKAP110 family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microfilament
    basic FUNCTION
  • a kinase (PRKA regulatory subunit RIIA) anchor protein tethering the enzyme near its physiological substrate
  • may be involved in oocyte recognition
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to SPA17 in spermatozoa (binds the RII binding domain of AKAP3 along the length of the flagella)
  • cell & other
  • sperm-oocyte binding
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    correlates with poor prognosis in epithelial ovarian cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS