Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol AKAP11 contributors: mct - updated : 19-01-2013
HGNC name a kinase (PRKA) anchor protein 11
HGNC id 369
Location 13q14.11      Physical location : 42.846.288 - 42.897.402
Synonym name
  • A-kinase anchoring protein, 220kDa
  • protein kinase A anchoring protein
  • Synonym symbol(s) KIAA0629, AKAP220, FLJ11304, PRKA11
    DNA
    TYPE functioning gene
    STRUCTURE 51.11 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked   status provisional
    Map cen - D13S168 - AKAP11 - CPB2 - D13S153 - qter
    Authors GeneMap (98)
    Physical map
    FOXO1A 13q14.1 forkhead box O1A (rhabdomyosarcoma) MRPS31 13q13.2 mitochondrial ribosomal protein S31 SLC25A15 13q14 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 HCP34 13q14.11 cytochrome c, somatic pseudogene ELF1 13q13 E74-like factor 1 (ets domain transcription factor) WBP4 13q13.3 WW domain binding protein 4 (formin binding protein 21) KBTBD6 13q13.3 kelch repeat and BTB (POZ) domain containing 6 LOC390398 13 similar to calmodulin 1; Calmodulin 1 (phosphorylase kinase, delta) KBTBD7 13q13.3 kelch repeat and BTB (POZ) domain containing 7 MTRF1 13q14.1-q14.3 mitochondrial translational release factor 1 FLJ22054 13q13.3 hypothetical protein FLJ22054 LOC387922 13 similar to tubulin, beta 5 LOC390399 13 similar to olfactory receptor MOR145-1 OR7E37P 13q14.12 olfactory receptor, family 7, subfamily E, member 37 pseudogene RGC32 13q13.3 response gene to complement 32 KIAA0564 13q13.3 KIAA0564 protein DGKH 13q13.3 diacylglycerol kinase, eta MAPK6PS3 13q14.13 diacylglycerol kinase, eta LOC341651 13q13.3 similar to bA215B13.2 (fumarate hydratase (FH) pseudogene) AKAP11 13q14.3 a kinase (PRKA) anchor protein 11 FABP3P2 13q13-q14 fatty acid binding protein 3, pseudogene 2 TNFSF11 13q14 tumor necrosis factor (ligand) superfamily, member 11 FLJ40919 13q14.11 hypothetical protein FLJ40919 EPSTI1 13q13.3 epithelial stromal interaction 1 (breast) DNAJD1 13q14.1 DnaJ (Hsp40) homolog, subfamily D, member 1 FLJ10094 13q14.11 hypothetical protein FLJ10094 FLJ31846 13q14.11 hypothetical protein FLJ31846 FLJ38725 13q14.11 hypothetical protein FLJ38725 LOC283510 13q14.11 similar to Diacylglycerol kinase, zeta 104kDa
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 9926 220 1901 - 2002 12147701
    - - 5947 - 1469 - 2002 12147701
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
    Nervousbrain    
     nerve   highly
    Reproductivemale systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    secondary structure an amphipathic helix binding domain
    HOMOLOGY
    interspecies homolog to rattus A kinase anchoring protein AKAP220
    Homologene
    FAMILY AKAP110 family
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm
    text cytoplasmic in premeiotic pachytene spermatocytes and
    in the centrosome of developing postmeiotic germ cells, while a midpiece/centrosome localization was found in elongating
    spermatocytes and mature sperm
    basic FUNCTION
  • a kinase (PRKA,regulating subunit RIIA) anchor protein tethering the enzyme near its physiological substrate
  • may serve a function in cell cycle control of both somatic cells and germ cells in addition to its putative role in spermatogenesis and sperm function
  • playing a role in regulating the Rb pathway, and its dysregulation may contribute significantly to alterations in cell cycle regulation
  • role for this anchored kinase/microtubule effector protein network in the propagation of cell motility
  • organizes IQGAP1 and GSK3B at the leading edge of motile cells in response to growth factors
  • participates in the integration and processing of calcium and cAMP signals that underlie directional mobilization of a microtubule-associated network at the leading edge of cells
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • formation of an IQGAP2-AKAP11 core complex initiates a subsequent phase of protein recruitment that includes the small GTPase Rac
  • AKAP11 serves as a platform for the assembly of a CLASP2-IQGAP sub-complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IQGAP2 and AKAP11 act synergistically to sustain PKA-mediated recruitment of effectors such as Rac GTPases that impact the actin cytoskeleton
  • AKAP11 interacts with the cytoskeletal scaffolding protein IQGAP1 to influence cell motility
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in oral cancer
    tumoral        
    alters the rate of microtubule polymerization and the lateral tracking of growing microtubules and retards cell migration in metastatic human cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS