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FLASH GENE
Symbol AKAP10 contributors: mct - updated : 20-04-2013
HGNC name a kinase (PRKA) anchor protein 10
HGNC id 368
Location 17p11.2      Physical location : 19.808.751 - 19.881.129
Synonym name
  • dual specificity A kinase-anchoring protein 2
  • mitochondrial A kinase PPKA anchor protein 10
  • Synonym symbol(s) DAKAP2, D-AKAP2, AKAP-10, D-AKAP-2, PRKA10
    DNA
    TYPE functioning gene
    STRUCTURE 73.40 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    FLJ22659 17p11.2 hypothetical protein FLJ22659 LOC388348 17 LOC388348 EPN2 17p11.2 epsin 2 EPPB9 17p11.2 B9 protein MAPK7 17p11.2 mitogen-activated protein kinase 7 MFAP4 17p11.2 microfibrillar-associated protein 4 ZNF179 17p11.2 zinc finger protein 179 LOC125208 17p11 ribosomal protein S2 pseudogene LOC390773 17 similar to Rpl17 protein FLJ10847 17p11.2 hypothetical protein FLJ10847 LOC388350 17 LOC388350 LOC388351 17 similar to hypothetical protein FLJ10847 ALDH3A2 17p11.2 aldehyde dehydrogenase 3 family, member A2 FLJ31196 17p11.2 hypothetical protein FLJ31196 ALDH3A1 17p11.2 aldehyde dehydrogenase 3 family, memberA1 ULK2 17p11.2 unc-51-like kinase 2 (C. elegans) AKAP10 17p11.2 a kinase (PRKA) anchor protein 10 HCMOGT-1 17p11.2 sperm antigen HCMOGT-1 LOC147150 17p11.2 similar to yeast Upf3, variant A pseudogene LOC347717 17p11.1 signal recognition particle 68kD pseudogene LOC347716 17p11.1 TL132 pseudogene LOC284193 17p11.2 nitric oxide synthase 2A pseudogene LOC284194 17p11.2 galectin-9 pseudogene LOC347719 17p11.2 karyopherin (importin) beta 2 pseudogene
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 3941 - 662 - 2009 19797056
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two tandem regulator of G-protein signaling (RGS) domains, interacting with RAB11A and GTP-bound RAB4A
  • the C terminal R binding motifs
  • secondary structure an amphipathic helix binding domain
    HOMOLOGY
    interspecies homolog to murine Akap10
    Homologene
    FAMILY
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • a kinase (PRKA regulatory subunits RIA and RIIA) anchor protein 10 in the mitochondrial and/or the plasma membrane tethering the enzyme near its physiological substrate
  • regulates the morphology of the RAB11A-containing compartment, with co-expression causing accumulation of both proteins on enlarged endosomes
  • potentially promotes accumulation of recycling proteins in the RAB4A/RAB11A-positive endocytic recycling compartment
  • AKAP10 mediated prostaglandin E2 potentiation of the expression of cytokines IL10 and IL6, modulating Toll-like receptor signaling in alveolar macrophages
  • may play an important role in the development and progression of colorectal cancer
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with PDZK1 in renal proximal tubular cells
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to arrhythmias and sudden cardiac death
    Variant & Polymorphism other
  • AKAP10 Val allele may modulate the sensitivity of cardiac pacemaker cells to autonomic inputs, possibly conferring risk for arrhythmias and sudden cardiac death
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS