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FLASH GENE
Symbol AKAP1 contributors: mct - updated : 06-03-2015
HGNC name a kinase (PRKA) anchor protein 1
HGNC id 367
Location 17q22      Physical location : 55.162.552 - 55.198.709
Synonym name
  • gravin
  • spermatid A-kinase anchor protein 84
  • dual-specificity A-kinase anchoring protein 1
  • protein kinase A1
  • Synonym symbol(s) AKAP121, AKAP149, SAKAP84, AKAP84, D-AKAP1, MGC1807, AKAP, PRKA1
    DNA
    TYPE functioning gene
    STRUCTURE 36.16 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 3801 - 593 highly expressed in prostate and small intestine 2007 17884635
  • also called D- AKAP1A or AKAP149
  • target to mitochondria
  • 11 splicing 3968 97.3 903 expressed in kidney, pancreas, liver, lung and brain 2007 17884635
  • also called D-AKAP1B or AKAP84
  • 33 additional residues N-terminal to N0 target to the endoplasmic reticulum (ER)
  • 12 - 4321 - 903 - 2007 17884635
    12 - 4048 - 903 - 2007 17884635
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
    Reproductivemale systemprostate   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Amphiphilic
    STRUCTURE
    motifs/domains
  • RNA binding motif KH and R binding motifs, and the KH motif binds short pyrimidine-rich RNA molecules with a stable hairpin structure
  • mitochondrial targeting domain positioned within the first 30 N-terminal residues
  • PRKA-binding domain resides in the middle segment of the molecule (residues 306,325)
  • secondary structure an amphipathic helix binding domain
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • a kinase (PRKA) anchor protein 1 in the mitochondrial membrane tethering the enzyme near its physiological substrate
  • playing an essential role in oxidative metabolism and cell survival
  • assembles a multivalent signaling complex on the outer mitochondrial membrane that controls persistence and amplitude of cAMP and src signaling to mitochondria
  • may regulate myofibrillogenesis and myocyte remodeling during heart disease
  • through its role in enhancing cAMP and tyrosine kinase signaling to distal organelles, is an important regulator in mitochondrial metabolism
  • negative regulator of cardiomyocyte hypertrophy
  • regulates the response to stress in cardiomyocytes, and therefore its downregulation might represent an important event contributing to the development of cardiac dysfunction
  • controls mitochondria dynamics through PRKAA-dependent inhibitory phosphorylation of DNM1L and PRKAA-independent inhibition of DNM1L-FIS1 interaction
  • AKAP1 and PPP2R4 regulate neuronal morphogenesis via DNM1L phosphorylation and mitochondrial bioenergetics
  • potentially anchoring STAR mRNA at the mitochondria, thus stabilizing the translational complex at this organelle, a situation that might affect STAR production and steroidogenesis
  • AKAP1-PRKACA-PDE4A distribution and integrity have a key role in cellular survival
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • type I and type II, PRKA regulatory subunits
  • binding PTPN21, a novel positive regulator of SRC signaling
  • interacting with SIAH2 (binds to, and promotes its proteasomal degradation)
  • targets SRC tyrosine kinase to mitochondria via PTPN21
  • ABCF1, AKAP1, CPE, DOPEY1 and GOPC may be targeted specifically by the initiator CASP8 and CASP10 during the early stages of apoptosis
  • interacts with STAR mRNA in a dibutyryl-cAMP-stimulated human steroidogenic adrenocortical carcinoma cell line
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS