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FLASH GENE
Symbol AK5 contributors: SGE/npt - updated : 06-11-2009
HGNC name adenylate kinase 5
HGNC id 365
Location 1p31      Physical location : 77.747.741 - 78.025.652
Synonym name
  • ATP-AMP transphosphorylase
  • adenylate kinase 6
  • Synonym symbol(s) AK6, MGC33326
    EC.number 2.7.4.3
    DNA
    TYPE functioning gene
    STRUCTURE 277.91 kb     14 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    MGC22773 1p31.1 hypothetical protein MGC22773 FPGT 1p31.1 fucose-1-phosphate guanylyltransferase CARK DKFZp547I048 1p31.1 hypothetical protein DKFZp547I048 CRYZ 1p31-p22 crystallin, zeta (quinone reductase) LOC388640 1 similar to crystallin, zeta; NADPH:quinone reductase LOC127253 1p31.1 hypothetical protein BC009514 LOC148864 1p31.1 similar to LIM homeo domain transcription factor MGC34032 1p31.1 hypothetical protein MGC34032 LOC388641 1 LOC388641 LOC343221 1p31.1 similar to KIAA0433 protein ACADM 1p31 acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain DLSTP 1p31 dihydrolipoamide S-succinyltransferase pseudogene (E2 component of 2-oxo-glutarate complex) RABGGTB 1p31 Rab geranylgeranyltransferase, beta subunit MSH4 1p31 mutS homolog 4 (E. coli) ASB17 1p31.1 ankyrin repeat and SOCS box-containing 17 SIAT7C 1p31.1 sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) C LOC388642 1 similar to Triosephosphate isomerase (TIM) LOC388643 1 LOC388643 SIAT7E 1p31.1 sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) E LOC256483 1p31.1 hypothetical LOC256483 PIGK 1p31.1 phosphatidylinositol glycan, class K AK5 1p31 adenylate kinase 5 DKFZP564I052 USP33 1p31.1 ubiquitin specific protease 33 FLJ35093 1p31.1 FLJ35093 protein LOC91624 FUBP1 1p31.1 far upstream element (FUSE) binding protein 1 DNAJB4 1p31.1 DnaJ (Hsp40) homolog, subfamily B, member 4 LOC339425 1p31.1 similar to Nit protein 2 GIPC2 1p31.1 PDZ domain protein GIPC2 LOC388644 1 hypothetical gene supported by AK091757 PTGFR 1p31.1 prostaglandin F receptor (FP) C1orf29 1p31.1 chromosome 1 open reading frame 29 IFI44 1p31.1 interferon-induced protein 44 LOC343295 1p31.1 similar to Nuclear protein SkiP (Ski-interacting protein) (SNW1 protein) (Nuclear receptor coactivator NCoA-62) ELTD1 1p33-p32 EGF, latrophilin and seven transmembrane domain containing 1 LOC149050 1p31.1 similar to phosphoserine aminotransferase isoform 1 LOC343296 1p31.1 similar to Alcohol dehydrogenase class III chi chain (Glutathione-dependent formaldehyde dehydrogenase) (FDH) LOC391049 1 similar to Rda288-prov protein COX6A1P 1p31.1 cytochrome c oxidase subunit VIa polypeptide 1 pseudogene
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 3962 - 536 - -
  • isoform 2
  • 14 - 3257 - 562 - -
  • isoform 1
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   specific
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two separate functional domains, both having enzymatic activity (Solaroli 2009)
  • HOMOLOGY
    interspecies homolog to murine Ak5 (91.5pc)
    Homologene
    FAMILY
  • adenylate kinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP binding
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS