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FLASH GENE

Symbol

AJUBA

contributors: mct - updated : 19-05-2010

HGNC name	ajuba LIM protein
HGNC id	20250

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	14q11.2      Physical location : -
Synonym name	protein ajuba
	jub, ajuba homolog (Xenopus laevis)
Synonym symbol(s)	MGC15563, JUB

DNA

TYPE	functioning gene
STRUCTURE	11.44 kb     8 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_032876 8 - 4236 NP_116265 - 538 - 2006 16713569 NM_198086 6 - 3263 NP_932352 - 121 - 2006 16713569

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly   mouth tongue     highly Reproductive female system uterus cervix   highly Skeleton axial skull face mandible

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo, fetal

Text	expressed in totipotent embryonic stem cells, in the embryonic yolk sac, and in the fetal liver

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

three LIM zinc-binding domains

HOMOLOGY

Homologene

FAMILY	zyxin/ajuba family
	Ajuba LIM proteins family

CATEGORY

adaptor , transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
	intracellular,nucleus
text	associates with the actin cytoskeleton near the adhesion plaques
	localizes to basal bodies of cilia in growth-arrested cells
	cytoplasmic protein that can shuttle into the nucleus (Hou 2010)

basic FUNCTION	may be a component of a signal transduction pathway mediating adhesion-stimulated changes in gene expression
	may be contributing to the bridging of the cadherin adhesive complexes to the actin cytoskeleton and to the formation of cadherin-mediated cell-cell adhesion
	function as corepressors for SNAI1 and, as such, may serve as a platform for the assembly of chromatin-modifying factors
	having a role in the regulation of vertebrate ciliogenesis and left-right axis determination
	functions as a nuclear receptor corepressor and negatively regulates retinoic acid signaling
	adaptor protein that exhibit the potential to communicate cell adhesive events with nuclear responses to remodel epithelia
	having role as negative regulatorof the Hippo signaling pathway
	required for microRNA-mediated gene silencing

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	component at cadherin-mediated cell-cell junction
	AKT1-PAK1-AJUBA feedback loop integrates spatiotemporal signaling with actin remodeling at cell-cell contacts and stabilizes preassembled cadherin complexes

INTERACTION

DNA

RNA

small molecule

protein	binding AURKA in mitotic cells
	corepressor of GFI1 (SNAG domain of GFI1 may bind Ajuba, trapping it in the nucleus where it functions as an adapter or molecular scaffold for the assembly of macromolecular repression complexes at target promoters)
	directly interacts with RARA via its conserved nuclear-receptor binding motifs in a ligand-dependent manner
	bound directly to AKT1·GDP or AKT1·GTP, but phosphorylated AJUBA interacted preferentially with active AKT1

cell & other

REGULATION

Phosphorylated by

PAK1, that transiently activated upon cell-cell adhesion and directly phosphorylated AJUBA (Thr172)

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS