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FLASH GENE
Symbol AIMP2 contributors: mct/ - updated : 26/09/2008
HGNC name aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
HGNC id 20609
Location 7p22.1      Physical location : 6.048.881 - 6.063.464
Synonym name
  • protein JTV-1
  • aminoacyl tRNA synthetases-interacting multi-functional protein 2
  • multisynthetase complex auxiliary component p38
  • ARS-interacting multi-functional protein 2
    • Synonym symbol(s) P38, PRO0992, JTV-1, JTV1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE overlapping, gene in gene, opposite orientation
    text
  • overlapping PMS2
  • transcribed in opposite orientation of PMS2 and HRI
    • STRUCTURE 14.58 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1236 35 320 - 2005 16125937
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Lymphoid/Immunelymph node   highly
    Reproductivefemale systemovary  highly
    Skin/Tegumentskin   highly
    Visualeye   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one GST-like domain
    • HOMOLOGY
    intraspecies homolog to GSTM1
    Homologene
    FAMILY
  • glutathione S-transferase family
    • CATEGORY storage
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • mediating ubiquitination of FUBP1 and its degradation by the proteasome
  • scaffolding protein required for the assembly of the macromolecular tRNA synthetase complex
  • may control tRNA synthesis in coordination with p53 activation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the translational machinery, functioning as proapoptotic factor via TP53 in response to DNA damage
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • positive regulator of 53 in response to genotoxic stresses
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS