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FLASH GENE
Symbol AIM1 contributors: mct - updated : 22-12-2015
HGNC name absent in melanoma 1
HGNC id 356
Location 6q21      Physical location : 106.959.729 - 107.018.332
Synonym name
  • suppression of tumorigenicity 4
  • beta-gamma crystallin domain containing 1
    • Synonym symbol(s) ST4, CRYBG1
    DNA
    TYPE functioning gene
    STRUCTURE 58.61 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 7562 188.5 1723 - 2000 10797266
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart     Homo sapiens
    Reproductivefemale systemplacenta    Homo sapiens
    Urinarykidney     Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    IMPRINTING maternally
    text paternally expressed and methylated specifically on the maternal allele in the human placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve structural motifs, arranged in four ABAB patterns, characteristic of the beta-gamma crystallin superfamily, 12 betagamma-crystallin motifs in six domains
  • six tandems repeats
  • one ricin b-type lectin domain
    • HOMOLOGY
    interspecies homolog to murine Aim1
    Homologene
    FAMILY
  • beta/gamma-crystallin family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • mitotic regulator playing a key role in the onset of cytokinesis during mitosis
  • involved in the control of tumorigenicity in malignant melanoma
  • AIM1 protein sequence has a weak similarity with filament or actin-binding proteins, indicating a possible role in the management of cell morphology and shape
  • significantly suppressed during melanoma progression
  • high AIM1 and TMED3 expression associates with genes involved in lipid metabolism, and high ERGIC1 and TMED3 expression with genes involved in redox homeostasis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
  • cytoskeleton
    • REGULATION
    Other demethylation of AIM1 promoter region can re-activate AIM1 mRNA expression, suggesting promoter region methylation regulates AIM1 expression
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate cancer tissues
    tumoral     --low  
    by promoter hypermethylation identified in 65p100 of metastatic melanomas, as compared to 38p100 of primary melanomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    induction of apoptosis due to AIM1 and TMED3 inhibition especially in the androgen independent prostate cancer cells
    ANIMAL & CELL MODELS