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FLASH GENE
Symbol AIG1 contributors: mct - updated : 05-01-2015
HGNC name androgen-induced 1
HGNC id 21607
Location 6q24.1      Physical location : 143.382.022 - 143.661.439
Synonym name androgen induced protein (AIG-1), C-terminus truncated
Synonym symbol(s) AIG-1, FLJ10485, dJ95L4.1
DNA
TYPE functioning gene
STRUCTURE 279.42 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1385 - 238 - 2011 21622095
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Urinarybladder   highly
 kidney   highly
Visualeyeanterior segmentiris  
 eyeretina   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Respiratoryepithelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
five hydrophobic domains
HOMOLOGY
Homologene
FAMILY AIG1 family
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
basic FUNCTION
  • may have functions in the androgen-regulated hair cycle
  • both AIG1 and ADTRP hydrolyze bioactive fatty acid esters of hydroxy fatty acids (FAHFAs) but not other major classes of lipids
  • AIG1 and ADTRP are founding members of an evolutionarily conserved class of transmembrane threonine hydrolases involved in bioactive lipid metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a novel RCHY1-interacting protein, that activates the NFAT signaling pathway
  • cell & other
    REGULATION
    induced by androgens
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • could serve as a new biomarker for the diagnosis and prognostic evaluation of hepatocellular carcinomas (PMID;
  • Therapy target
    ANIMAL & CELL MODELS