| basic FUNCTION
| single-stranded DNA deaminase required for somatic hypermutation of Ig genes |
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modulator of Ig gene information, putatively involved in editing |
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functions distributively whereas cytoplasmic APOBEC3G has a processive mode of action  |
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controlling all B cell-specific modification of Ig gene Ig-class switch recombination (CSR) and IgV somatic hypermutation (SHM) |
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deaminates deoxycytidine residues in immunoglobulin genes, triggering antibody diversification |
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having many of the properties of RNA-editing enzymes, including nucleocytoplasmic shuttling and a dependency on de novo protein synthesis ( |
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required for germinal center-derived lymphomagenesis |
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essential factor for the class switch recombination (CSR) and somatic hypermutation (SHM) of Ig genes |
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having a function associated with its C-terminus and required for recombination of the cleaved S region |
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at least 2 different functions: DNA cleavage, which occurs without the C-terminal region, and a recombination-specific function that requires the C-terminal region responsible for the nuclear export by the NES motif and the association with polyA+ RNA |
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plays a central role in the synthesis of high affinity antibodies |
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with APOBEC3G, catalyzes deamination of cytosine to uracil on single-stranded DNA |
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during immunoglobulin class-switch recombination (CSR), induces double-strand breaks into transcribed, repetitive DNA elements called switch sequences |
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APOBEC3B and AICDA have similar nuclear import mechanisms |
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is an important contributor to the antibody-independent role of B cells in autoimmunity |
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enzyme responsible for somatic hypermutation and immunoglobulin heavy chain class switch recombination |
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critical role for AICDA activity in the initiation of reprogramming to induced pluripotent stem cells (iPSCs) |
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role for AICDA in epigenetic reprogramming and control of gene expression |
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deaminates genomic deoxycytosine bases within the immunoglobulin locus, activating downstream repair pathways that result in antibody maturation |
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initiates the antibody diversification processes in activated B cells by deaminating cytosine to uracil in immunoglobulin genes |
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triggers antibody class switch recombination (CSR) in B cells by initiating DNA double strand breaks that are repaired by nonhomologous end-joining pathways |
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initiates mutagenic pathways to diversify the antibody genes during immune responses |
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is essential for antibody class switch recombination (CSR) and somatic hypermutation (SHM) |
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contributes to the development of pancreatic precancerous lesions by inducing tumor-related gene mutations |
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deaminates cytosines in DNA to initiate immunoglobulin gene diversification and to reprogram CpG methylation in early development |
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implicated in DNA demethylation through its deaminase activity coupled with DNA repair |
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is essential for the somatic hypermutation (SHM) and class-switch recombination (CSR) of Ig genes |
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AICDA-structure-specific cofactor complex formations differentially contribute to its DNA-cleavage and recombination functions |
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B-cell-specific enzyme that targets immunoglobulin genes to initiate class switch recombination and somatic hypermutation |
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mediates class switching by binding to a small fraction of single-stranded DNA (ssDNA) to diversify the antibody repertoire |
