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FLASH GENE
Symbol AHRR contributors: npt/ - updated : 10-04-2007
HGNC name aryl-hydrocarbon receptor repressor
HGNC id 346
Location 5p15.33      Physical location : 304.290 - 438.403
Synonym name
  • aryl hydrocarbon hydroxylase regulator
  • class E basic helix-loop-helix protein 77
  • dioxin receptor repressor
    • Synonym symbol(s) AHH, AHHR, KIAA1234, bHLHe77, MGC167813, MGC176630
    EC.number 1.14.14.1
    DNA
    TYPE functioning gene
    STRUCTURE 134.12 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    Binding site   HRE
    text structure
  • xenobiotic responsive element (regulatory DNA sequence), three conserved XRE sequences in the 5
    • -flanking promoter region
  • NFKB binding sites
    • MAPPING cloned   linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 5661 - 719 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbraindiencephalonamygdala  
     braindiencephalonhypothalamus  
     nerve   highly
    Reproductivefemale systemuteruscervix highly
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • PAS domain
  • basic helix-loop-helix (bHLH) domain
  • a transcriptional repression domain within its C-terminal region, which exhibits a trichostatin A (TSA)-sensitive HDAC activity, interacting with ANKRA2
    • HOMOLOGY
    interspecies homolog to murine Ahr repressor
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,nucleus
    basic FUNCTION
  • may mediate Ca(2+)- regulated signals along the death pathway
  • inhibit Aryl hydrocarbon receptor (AHR) activity by competing with AHR for forming a heterodimer with AHR nuclear translocator (ARNT)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ANKRA2 (ANKRA2 is important for transcriptional repression by AHRR)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in early stages of non-small cell lung cancer (Kang 2008)
    Susceptibility to micropenis(MP)
    Variant & Polymorphism other Pro185Ala polymorphism may constitute a susceptibility locus for the development of MP in response to dioxins
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS