| basic FUNCTION
| retained in cytoplasm in resting state in association with HSP90, and with AIP (AH receptor associated protein 9) |
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released after exposure to xenobiotics |
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ligand-activated transcription factor, mediating xenobiotic signaling to enhance the expression of target genes, including drug-metabolizing cytochrome P450s |
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involved in xenobiotic induced regulation of the UGT1A3  |
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having a proproliferative, antiapoptotic function that likely plays a role in tumor progression |
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mediates most, if not all, of the many toxicological effects of the environmental pollutant 2,3,7,8-tetrachlorodibenzo- p-dioxin [(TCDD) or dioxin |
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its activation inhibits differentiation of human monocytes and Langerhans dendritic cells |
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plays an essential role in the toxic response to environmental pollutants |
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modulates expression of human MT2A via the glucocorticoid response element and protein-protein interactions with glucocorticoid receptor (GR) |
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HSP90AA1 was co-localized with AHR after the nuclear translocation |
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in osteoclast lineage cells are a negative regulator of bone mass |
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regulatory role of AHR in not only adaptive but also innate lymphocytes including recently discovered innate lymphoid cells |
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role of AHR signaling in the gene regulation of epidermal barrier proteins |
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modulates the degradation of proteins involved in cell cycle control, consistent with previous reports demonstrating an essential role of the AHR in cell cycle regulation |
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plays an important role in the pathogenesis of retinal diseases including age-related macular degeneration |
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untimely expression of the Ahr gene needs to be repressed to maintain ES cell mitotic progression and prevent premature loss of pluripotency |
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functional AHR expression is critical for skin barrier integrity and that AHR represents a molecular target for the development of therapeutic approaches for skin barrier diseases, including by dietary intervention |
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is a transcription factor modulated by exogenous and endogenous ligands that is important in the homeostasis of immune cells at barrier sites, such as the skin and gut |
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protective role of the AHR against carcinogenesis and oxidative stress because causal role of the AHR in the antioxidant response |
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is required for optimal B-cell proliferation |
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recognizes xenobiotics as well as natural compounds such as tryptophan metabolites, dietary components and microbiota-derived factors, and it is important for maintenance of homeostasis at mucosal surfaces |
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AHR-induced inhibition that influences circadian rhythm amplitude |
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ligand-activated transcription factor that is known as a mediator of toxic responses |
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plays an important physiological role in hematopoiesis |
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regulates early human hemato-lymphoid cell development and may be targeted to enhance production of specific cell populations derived from human pluripotent stem cells |
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ligand-activated transcription factor whose activity is regulated by small molecules provided by the diet, the commensal flora, environmental pollutants and the metabolism |
