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FLASH GENE
Symbol AHCYL2 contributors: mct/npt - updated : 04-02-2009
HGNC name S-adenosylhomocysteine hydrolase-like 2
HGNC id 22204
Location 7q32.1      Physical location : 128.864.854 - 129.070.051
Synonym name
  • putative adenosylhomocysteinase 3
  • KIAA0828 protein
  • adenosylhomocysteinase 3
  • Synonym symbol(s) KIAA0828, FLJ21719, long IRBIT
    EC.number 3.3.1.1
    DNA
    TYPE functioning gene
    STRUCTURE 205.20 kb     17 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 5070 66 611 - LLeonart (2006)
    - - 5061 56.8 508 - LLeonart (2006)
    - - 5064 57 509 - LLeonart (2006)
    - - 5067 66.5 610 - LLeonart (2006)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Digestiveintestine   highly
     mouthtongue  moderately
    Nervousspinal cord   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Epithelialbarrier liningretinal pigment epithelium (RPE)  
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to AHCYL1
    Homologene
    FAMILY
  • adenosylhomocysteinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • having adenosylhomocysteinase activity
  • modulating TP53-dependent function and avoid senescence (Lleonart 2006)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism monocarbon
    signaling
    one-carbon compound metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • one NAD per subunit
  • protein
  • potential regulator of SLC4A4 in mammalian cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in colon carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS