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FLASH GENE
Symbol AGPAT2 contributors: mct - updated : 13-10-2006
HGNC name 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)
HGNC id 325
Corresponding disease
BSCL1 Berardinelli-Seip congenital generalized lipodystrophy type 1
Location 9q34.3      Physical location : 139.567.594 - 139.581.911
Synonym name
  • 1- AGP acyltransferase 2
  • lysophosphatidic acid acyltransferase-beta
  • 1-acylglycerol-3-phosphate O- acyltransferase 2
  • LPAAT-beta
    • Synonym symbol(s) LPAATB, PLCB, BSCL, LPAAB
    EC.number 2.3.1.51
    DNA
    TYPE functioning gene
    STRUCTURE 14.32 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1576 30.9 278 - -
    5 - 1480 - 246 - -
    lacks an alternate in-frame exon
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   lowly
    Endocrinepancreas   highly
    Respiratorylung   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four conserved motifs (I–IV), whose invariant residues appear to be important for catalysis and/or substrate recognition )
    • HOMOLOGY
    interspecies homolog to murine Agpat1
    intraspecies homolog to AGPAT1
    Homologene
    FAMILY
  • 1-acyl-sn-glycerol three phosphate acyltransferase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • lysophosphatidic acid acyltransferase (beta), catalyzing the conversion of lysophosphatidic acid to phosphatidic acid
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    second step in phospholipid biosynthesis, fatty acid and sterol
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BSCL1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS