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FLASH GENE

Symbol

AGPAT1

contributors: mct - updated : 29-10-2010

HGNC name	1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
HGNC id	324

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6p21.3      Physical location : 3.397.002 - 32.145.888
Synonym name	major histocompatibility class III region, G15 (see HTFAG@)
	lysophosphatidic acid acyltransferase alpha
	protein G15
Synonym symbol(s)	LPAATA, LPAAT-alpha, G15, MGC4007, MGC5423, 1-AGPAT1
EC.number	2.3.1.51

DNA

TYPE	functioning gene
STRUCTURE	9.91 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_032741 7 - 2049 NP_116130 31.7 283 - 2007 17707131 NM_006411 7 - 2259 NP_006402 31.7 283 - 2007 17707131

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine adrenal gland       highly   thyroid       highly Skin/Tegument skin       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a transmembrane domain is predicted to separate motif I on the cytosolic side from motifs II-III on the lumenal side, with motif IV near surface of the membrane (motifs II and III are involved in lysophosphatidic acid binding and motifs I and IV are involved in acyl-CoA binding)
	four conserved motifs (I–IV), whose invariant residues appear to be important for catalysis and/or substrate recognition

HOMOLOGY

Homologene

FAMILY

1-acyl-sn-glycerol-3-phosphate acyltransferase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
	intracellular,cytoplasm,cytosolic

basic FUNCTION	catalyzing the conversion of lysophosphophatidic acid to phosphatidic acid
	involved in de novo biosynthesis of glycerolipids, such as phospholipids and triacylglycerol
	implicated in the development of skeletal muscle, specifically to terminal differentiation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

lipid/lipoprotein

signaling

second step in de novo phospholipid biosynthesis

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS