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FLASH GENE
Symbol AGPAT1 contributors: mct - updated : 29-10-2010
HGNC name 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
HGNC id 324
Location 6p21.3      Physical location : 3.397.002 - 32.145.888
Synonym name
  • major histocompatibility class III region, G15 (see HTFAG@)
  • lysophosphatidic acid acyltransferase alpha
  • protein G15
  • Synonym symbol(s) LPAATA, LPAAT-alpha, G15, MGC4007, MGC5423, 1-AGPAT1
    EC.number 2.3.1.51
    DNA
    TYPE functioning gene
    STRUCTURE 9.91 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2049 31.7 283 - 2007 17707131
    7 - 2259 31.7 283 - 2007 17707131
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
     thyroid   highly
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a transmembrane domain is predicted to separate motif I on the cytosolic side from motifs II-III on the lumenal side, with motif IV near surface of the membrane (motifs II and III are involved in lysophosphatidic acid binding and motifs I and IV are involved in acyl-CoA binding)
  • four conserved motifs (IIV), whose invariant residues appear to be important for catalysis and/or substrate recognition
  • HOMOLOGY
    Homologene
    FAMILY
  • 1-acyl-sn-glycerol-3-phosphate acyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzing the conversion of lysophosphophatidic acid to phosphatidic acid
  • involved in de novo biosynthesis of glycerolipids, such as phospholipids and triacylglycerol
  • implicated in the development of skeletal muscle, specifically to terminal differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    second step in de novo phospholipid biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS