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FLASH GENE
Symbol AGO1 contributors: mct/npt - updated : 26-03-2016
HGNC name argonaute RISC catalytic component 1
HGNC id 3262
Location 1p34.3      Physical location : -
Synonym name
  • golgi endoplasmic reticulum protein 95 kDa
  • argonaute 1
  • putative RNA-binding protein Q99
  • eukaryotic translation initiation factor 2C, 1
    • Synonym symbol(s) Q99, EIF2C1, EIF2C, GERP95, DKFZp686M13167
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text in a cluster of closely related family members including argonaute 3, and argonaute 4
    STRUCTURE 46.40 kb     19 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 7478 97.1 857 - 2003 1290685
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES basic
    STRUCTURE
    motifs/domains
  • N-terminal, PAZ, Mid and PIWI domains
  • multiple short repeated segments composed of interspersed mono, tri or quadrinucleotides
  • one PAZ (Piwi/argonaute/Zwille ) domain to bind RNA
  • one PIWI domain
  • a Mid domain that interact with small RNA molecules and proteins involved in translation
    • HOMOLOGY
    interspecies homolog to rattus Eif2c1 (99.9pc)
    homolog to murine Eif2c1 (99.5pc)
    homolog to Drosophila AGO1 (75pc)
    Homologene
    FAMILY
  • Argonaute/PIWI protein family
    • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • concentrated in cytoplasmic bodies
  • nuclear import of Ago proteins in cells influenced by IPO8 (Weinmann 2009)
  • distributed uniformly in the nucleus and cytosol in early embryos but accumulated predominantly in the cytoplasm during the gastrulation stage
    • basic FUNCTION
  • playing an important role in the eukaryotic peptide chain initiation process
  • playing a role in short-interfering-RNA-mediated gene silencing
  • critical for FMR1 function in neural development and synaptogenesis
  • may act as a tumor-suppressor factor
  • plays a crucial role in gene regulation and genome stability via biogenesis of small non-coding RNAs
  • AGO1 and AGO2 facilitate spliceosome recruitment and modulate POLR2A elongation rate, thereby affecting alternative splicing
  • AGO1-mediated translational desuppression of VEGFA may be associated with tumor angiogenesis and poor prognosis
  • nuclear AGO1 regulates the expression of EIF2C1-bound genes that are implicated in oncogenic pathways including cell cycle progression, growth, and survival
  • AGO1, AGO2 play a central role in the RNA interference (RNAi) pathway, which is a cytoplasmic mechanism important for post-transcriptional regulation of gene expression
    • CELLULAR PROCESS protein, translation regulation
    PHYSIOLOGICAL PROCESS
    text regulation of translational initiation
    PATHWAY
    metabolism
    signaling
    a component
  • putative accessory component of the ternary initiation complex made of E172, initiation Met-tRNA and GTP
  • eukaryotic translation initiation factor 2 complex
  • part of a protein complex that enhances translation of a transcript that is regulated by an AU-rich element in serum-starved cells
  • DICER1 and Argonaute 1-4 proteins (EIF2C1, EIF2C2, EIF2C3, EIF2C4) are key components of the cytoplasmic enzyme machinery responsible for biogenesis and performance of microRNAs
  • components of the RNA-induced silencing complex (RISC)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • dicer1
  • associates with RNA polymerase II (RNAPII) and required for histone H3 Lys9 dimethylation and transcriptional gene silencing
  • hypoxia-responsive microRNAs that are strongly induced in vascular endothelial cells, are induced by HIF1A and target argonaute 1 (AGO1), which anchors the microRNA-induced silencing complex (miRISC)
  • EIF2C1 interacts with POLR2A and binds to the promoters of actively transcribed genes in human cancer cells
    • cell & other
  • cellular binding partners of miRNAs as well as other small RNAs and are therefore key components of miRNP (Weinmann 2009)
    • REGULATION
    Other a selective process such as ubiquitylation can lead to the degradation of a key regulatory protein such as AGO1 by a degradation process generally believed to be unspecific
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS