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FLASH GENE

Symbol

AGBL5

contributors: mct/npt - updated : 05-10-2016

HGNC name	ATP/GTP binding protein-like 5
HGNC id	26147

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	RP75 retinitis pigmentosa 75
Location	2p23.3      Physical location : 27.274.490 - 27.293.489
Synonym name	cytosolic carboxypeptidase-like protein 5
Synonym symbol(s)	FLJ21839, CCP5
EC.number	3.4.17.-

DNA

TYPE	functioning gene
STRUCTURE	19.20 kb     14 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_021831 15 - 3254 NP_068603 97 886 - 2013 24022482 NM_001035507 11 - 2460 NP_001030584 - 717 - 2013 24022482

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system uterus cervix   highly   male system testis     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

peptidase M14 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
	intracellular,nucleus

basic FUNCTION	having a function in the processing of cytosolic proteins such as alpha-tubulin, which is known to be modified by the removal of a C-terminal tyrosine
	cleave C-terminal and/or side chain amino acids from tubulin
	functions as a dual-functional deglutamylase cleaving both alpha- and gamma-linked glutamate from tubulin
	regulates tubulin glutamylation, a functionally important tubulin posttranslational modification enriched on stable microtubules of neuronal axons, mitotic spindles, centrioles, and cilia

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

RP75

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS