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FLASH GENE

Symbol

AGBL1

contributors: mct/npt - updated : 25-11-2013

HGNC name	ATP/GTP binding protein-like 1
HGNC id	26504

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	FECD8 corneal dystrophy, Fuchs endothelial, 8
Location	15q25.3      Physical location : 86.685.241 - 87.572.283
Synonym name	cytosolic carboxypeptidase 4
Synonym symbol(s)	FLJ32310, CCP4, MGC149239
EC.number	3.4.17.-

DNA

TYPE	functioning gene
STRUCTURE	949.15 kb     24 Exon(s)

motif

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_152336 24 - 3493 NP_689549 120 1066 - 2013 24094747

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas         Reproductive male system prostate

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

peptidase M14 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
text	localizes predominantly to the cytoplasm, but in sharp contrast, the truncated protein showed distinct nuclear localization

basic FUNCTION

function in the processing of cytosolic proteins such as alpha-tubulin, which is known to be modified by the removal of a C-terminal tyrosine

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacts biochemically with the FECD-associated protein TCF4 (TCF4 might be an enzymatic target for AGBL1)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

FECD8

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS