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FLASH GENE
Symbol AEN contributors: npt - updated : 18-06-2010
HGNC name apoptosis enhancing nuclease
HGNC id 25722
Location 15q26.1      Physical location : 89.164.526 - 89.175.512
Synonym name interferon stimulated exonuclease gene 20kDa-like 1
Synonym symbol(s) FLJ12484, FLJ12562, pp12744, ISG20L1
EC.number 3.1.-.-
DNA
TYPE functioning gene
STRUCTURE 10.97 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 3134 - 325 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas    
Reproductivefemale systemuteruscervix highly
Skin/Tegumentskin    
Visualeye    
cell lineage
cell lines
fluid/secretion lymph
at STAGE
physiological period embryo
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an exonuclease domain
  • HOMOLOGY
    interspecies homolog to murine Isg20l1 (73.6pc)
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may contribute to radiation response during ionizing radiation-induced apoptosis by cooperatively cleaving DNA substrates along with other apoptotic nucleases and enhance apoptosis
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by irradiation
    p53
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS