basic FUNCTION
| may play a role in differentiated vascular smooth muscle cells |
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down-regulator of adipogenesis through its transcriptional repression activity, as well as through its interaction with mitogen-activated protein kinase (MAPK), which protects MAPK from its specific phosphatases |
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is a transcriptional repressor that impedes macrophage cholesterol efflux, promoting foam cell formation, via PPARG and NR1H3 down-regulation |
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plays critical regulatory roles in macrophage cholesterol homeostasis, foam cell formation, and proinflammation |
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macrophage AEBP1 plays critical regulatory roles in atherogenesis |
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role of AEBP1 in the signaling pathways regulating the cross-talk between mammary epithelium and stroma that could predispose the mammary tissue to tumorigenesis |
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stimulates the fibroblast-to-myofibroblast transition by promoting smooth muscle alpha-actin (SMA) expression via TGFB1 signaling and promoting collagen expression through a TGFB1 receptor-independent pathway |
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activates inflammatory responses via the NFKB1 pathway in macrophages and regulates adipogenesis in preadipocytes |
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has a role in the progression of Alzheimer pathology |
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involved in fibroblast proliferation and mesenchymal stem cell differentiation into collagen-producing cells |
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enhances collagen polymerization and binds to several fibrillar collagens via its discoidin domain |
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is likely involved in organization and remodeling of the ECM through direct binding of collagens and modulation of collagen fibrillogenesis |