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FLASH GENE

Symbol

ADTRP

contributors: mct - updated : 05-12-2018

HGNC name	androgen dependent TFPI regulating protein
HGNC id	21214

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6p24.1      Physical location : -
Synonym name	hypothetical protein LOC84830
	chromosome 6 open reading frame 105
Synonym symbol(s)	MGC12335, dJ413H6.1, RP3-413H6.1, C6orf105, AIG1L

DNA

TYPE	functioning gene
STRUCTURE	66.11 kb     6 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_032744 6 - 1812 NP_116133 26.7 230 - 2017 28645652 NM_001143948 7 - 1866 NP_001137420 - 248 - 2017 28645652

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine           stomach

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic plasma     highly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune macrophage Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	umbilical cord

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

DNA associated

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	both AIG1 and ADTRP hydrolyze bioactive fatty acid esters of hydroxy fatty acids (FAHFAs) but not other major classes of lipids
	AIG1 and ADTRP are founding members of an evolutionarily conserved class of transmembrane threonine hydrolases involved in bioactive lipid metabolism
	ADTRP increases the number of S phase cells during cell cycle, promotes cell proliferation, and inhibits apoptosis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	ADTRP-dependent up-regulation of TFPI expression and activity by androgen represents a novel mechanism of increasing the anticoagulant protection of the endothelium
	activation of PPARG increases, in a PPARG-dependent manner, the expression of ADTRP in human macrophages and atherosclerotic lesions
	ADTRP positively regulates PIK3R3 expression, which leads to activation of AKT1 and up-regulation of MIA3, thereby regulating endothelial cell functions directly relevant to atherosclerosis
	androgen inhibits key atherosclerotic processes by directly activating ADTRP transcription
	regulation of TFPI expression is likely one potential mechanism by which ADTRP regulates primitive myelopoiesis and definitive hematopoiesis
	POU1F1 is a transcription factor that regulates TFPI transcription in response to ADTRP

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

for contrary artery disease (CAD)

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS