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FLASH GENE
Symbol ADSS contributors: - updated : 04-07-2006
HGNC name adenylosuccinate synthase
HGNC id 292
Location 1cen-q12      Physical location : 244.571.796 - 244.615.413
Synonym name adenylosuccinate synthetase (Ade(-)H-complementing)
Synonym symbol(s) ADEH, MGC20404
EC.number 6.3.4.4
DNA
TYPE functioning gene
STRUCTURE 43.00 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
CHML 1q32-q41 choroideremia-like (Rab escort protein 2) FLJ32978 1q43 hypothetical protein FLJ32978 LOC391181 1 similar to 60S ribosomal protein L6 (TAX-responsive enhancer element binding protein 107) (TAXREB107) (Neoplasm-related protein C140) EXO1 1q43 exonuclease 1 LOC391182 1 similar to 60S ribosomal protein L23a FLJ40773 1q43 hypothetical protein FLJ40773 LOC391183 1 similar to ribosomal protein L24-like; 60S ribosomal protein L30 isolog; my024 protein; homolog of yeast ribosomal like protein 24 LOC391184 1 similar to RCC1-like LOC343365 1q43 similar to capicua homolog LOC388756 1 similar to hypothetical protein LOC349114 LOC388757 1 LOC388757 LOC339077 1q43 hypothetical gene supported by AK092558; AL137655; BC006361 KAB 1q44 KARP-1-binding protein SDCCAG8 1q44 serologically defined colon cancer antigen 8 AKT3 1q43-q44 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) LOC388758 1 LOC388758 LOC339529 1q44 hypothetical protein LOC339529 ZNF238 1q44-qter zinc finger protein 238 LOC343484 1q44 hypothetical LOC343484 LOC200159 1q44 hypothetical LOC200159 LOC126826 1q44 similar to TGFB-induced factor 2; TGF(beta)-induced transcription factor 2; transcription growth factor-beta-induced factor 2; homeobox protein TGIF2; 5-TG-3 interacting factor 2 ADSS 1cen-q12 adenylosuccinate synthase MGC33370 1q44 hypothetical protein MGC33370 HCP5 6p21.3 HLA complex P5 PNAS-4 1q44 CGI-146 protein LOC116228 1q44 hypothetical protein LOC116228 HNRPU 1q44 heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) MGC12458 1q44 hypothetical protein MGC12458 MGC35030 1q44 hypothetical protein MGC35030 FLJ10157 1q44 hypothetical protein FLJ10157 SMYD3 1q44 SET and MYND domain containing 3 LOC255654 1q44 hypothetical protein LOC255654 TFB2M 1q44 transcription factor B2, mitochondrial FLJ32001 1q44 hypothetical protein FLJ32001 CGI-49 1q44 CGI-49 protein LOC391185 1 similar to kinesin-like protein (103.5 kD) (klp-6) ELYS 1q44 ELYS transcription factor-like protein TMBS62 SBZF3 1q44 zinc finger protein SBZF3 MGC12466 1q44 hypothetical protein MGC12466
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Endocrineparathyroid   highly
Reproductivemale systemtestis  highly
Respiratoryrespiratory tracttrachea  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
Homologene
FAMILY adenylosuccinate synthetase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm
basic FUNCTION
  • adenylosuccinate synthase, purine nucleotide cycle
  • plays an important role in the de novo pathway of purine nucleotide biosynthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    binds 1 magnesium ion per subunit
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS