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FLASH GENE
Symbol ADRM1 contributors: mct/npt - updated : 10-10-2018
HGNC name adhesion regulating molecule 1
HGNC id 15759
Location 20q13.33      Physical location : 60.878.026 - 60.883.916
Genatlas name drm1
Synonym name
  • 110 kDa cell membrane glycoprotein
  • M(r) 110,000 surface antigen
  • regulatory particle non-ATPase 13
  • proteasome regulatory particle non-ATPase 13
  • 110 kDa cell membrane glycoprotein
  • Rpn13 homolog
  • Synonym symbol(s) ARM1, GP110, Rpn13, MGC29536
    DNA
    TYPE functioning gene
    STRUCTURE 6.80 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence cytosine-phosphate-guanine/HTF
    text structure 5-prime end of the cDNA is GC rich
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 splicing 1410 42 407 - 2016 27827410
  • variant 1
  • encoding the same protein than variant 2
  • a 17 aa signal peptide of 1.7 kda
  • a 390 aa mature peptide of 40.5 kda
  • 10 splicing 1406 42 407 - 2016 27827410
  • variant 2
  • differing in the 5' UTR compared to variant 1
  • encoding the same protein than variant 1
  • a 17 aa signal peptide of 1.7 kda
  • 390 aa mature peptide of 40.5 kda
  • 9 - 1379 - 368 - 2016 27827410
    9 - 1375 - 368 - 2016 27827410
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   highly
    Lymphoid/Immunespleen   highly
    Nervousbrain   highly
    Respiratorylung   moderately
    Skin/Tegumentskin   predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectiveadipose  moderately
    Connectivebone   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • extracellular domain rich in serine and threonine residues
  • a conserved N-terminal region termed the pleckstrin-like receptor for ubiquitin domain (Pru)
  • a DEUBAD domain in ADRM1 activating UCHL5
  • a C-terminal half binding directly to the proteasome-associated deubiquitinating enzyme, UCHL5, and enhancing its isopeptidase activity, and containing KEKE motifs
  • C-terminal region of ADRM1 binds to the tetratricopeptide repeat (TPR) domain of SGTA, a cytosolic factor implicated in the quality control of mislocalised membrane proteins (MLPs)
  • conjugated GlycoP , Other
    mono polymer heteromer , complex
    isoforms Precursor heavily glycosylated, which increased the mass of the 42-kDa peptide to 110 kDa
    HOMOLOGY
    interspecies homolog to rattus Adrm1 (96.6 pc)
    homolog to murine Adrm1 (96.6 pc)
    Homologene
    FAMILY
  • GP110 family
  • ADRM1 family
  • CATEGORY adhesion , regulatory , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • promoting cell adhesion
  • playing an important role for the binding of UCHL5 to the 19S complex and for efficient proteolysis
  • recruiting UCHL5, a deubiquitinating enzyme known to associate with 26 proteasomes
  • having a specialised role in proteasome function
  • acting as an activator of proteasome
  • acting as a ubiquitin receptor in the proteasome
  • recruits UCHL5, a deubiquitinating enzyme known to associate with 26 proteasomes (Hamazaki 2006)
  • essential for the activity of UCHL5 (Hamazaki 2006)
  • required for cell migration and osteoclast maturation (Kim 2009)
  • proteasome subunit that functions as novel ubiquitin receptor (Kim 2009)
  • a new ATP6V0D2-interacting protein, playing an important role in osteoclast differentiation, and in particular the fusion of preosteoclasts (Kim 2009)
  • is an intrinsic ubiquitin receptor of the 26S proteasome regulatory subunit that facilitates substrate capture prior to degradation
  • ADMR1 and PSMD4 function as ubiquitin receptors of the proteasome
  • ADRM1 mostly plays a redundant role with PSMD4 in recognition of ubiquitinated proteins and maintaining likely homeostasis
  • ADMR1 and UCHL5 are implicated in cell cycle progression, providing a rationale for their function in cellular proliferation
  • role of ADMR1 as a proteasomal ubiquitin receptor
  • CELLULAR PROCESS nucleotide, transcription, elongation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS immunity/defense
    text
  • tumor antigen
  • RNA elongation from RNA polymerase II promoter
  • PATHWAY
    metabolism
    signaling
    a component
  • component of the regulatory ATPase complex of the 26 S proteasome
  • INTERACTION
    DNA
    RNA
    small molecule other,
  • ubiquitin
  • protein
  • binding C-terminal tail domain of UCHL5, and relieved the autoinhibition
  • proteasome interacting protein
  • interaction between ATP6V0D2 and ADRM1 (Kim 2009)
  • interacting with UCHL5 (Nishio 2009)
  • phosphorylated TP63 induces transcription of ADRM1, leading to NOS2 protein degradation
  • UCHL5 is a de-ubiquitinating enzyme that is activated by ADRM1 and involved in the proteasomal degradation of proteins
  • interaction of PSMD1 with ADRM1 is controlled by SUMOylation in a manner that may alter proteasome composition and function
  • ADMR1 can activate UCHL5 by disrupting dimerization, although physiologically relevant activation likely results from stabilization of a surface competent for ubiquitin binding and modulation of the active-site crossover loop
  • binding of SGTA to ADRM1 enables specific polypeptides to escape proteasomal degradation and/or selectively modulates substrate degradation
  • ADRM1 plays an important role in mediating removal of mutant Htt aggregates when excess HAPF8A140 is present
  • direct interaction between SGTA and the proteasome, mediated by the intrinsic proteasomal ubiquitin receptor ADRM1 (27827410)
  • is recruited to the proteasome through direct interaction with the large scaffolding protein PSMD1 within the 19S regulatory particle
  • binds ubiquitin with an affinity similar to that of other proteasome-associated ubiquitin receptors
  • PSMD1, ubiquitin, and the deubiquitylase UCHL5 bind to ADRM1 with independent energetics
  • F8A1 -mediated reduction of ADRM1 alters the mitochondrial fission activity and results in mitochondrial fragmentation and mitochondrial dysfunction
  • cell & other
    REGULATION
    induced by interferon gamma
    Other acetylated
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    expression induced by gamma-interferon in gastric carcinoma
    tumoral     --over  
    in high grade serous carcinoma (HGSC) of the ovary and serous tubal intraepithelial carcinoma (STIC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    novel therapeutic target for ovarian cancer
    ANIMAL & CELL MODELS