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FLASH GENE
Symbol ADRM1 contributors: mct/npt - updated : 10-10-2018
HGNC name adhesion regulating molecule 1
HGNC id 15759
Location 20q13.33      Physical location : 60.878.026 - 60.883.916
Genatlas name drm1
Synonym name
  • 110 kDa cell membrane glycoprotein
  • M(r) 110,000 surface antigen
  • regulatory particle non-ATPase 13
  • proteasome regulatory particle non-ATPase 13
  • 110 kDa cell membrane glycoprotein
  • Rpn13 homolog
  • Synonym symbol(s) ARM1, GP110, Rpn13, MGC29536
    DNA
    TYPE functioning gene
    STRUCTURE 6.80 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence cytosine-phosphate-guanine/HTF
    text structure 5-prime end of the cDNA is GC rich
    MAPPING cloned Y linked N status confirmed
    Physical map
    CDH4 20q13.3 cadherin 4, type 1, R-cadherin (retinal) FLJ22202 20q13.33 hypothetical protein FLJ22202 TAF4 20q13.3 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa C20orf40 20q13.33 chromosome 20 open reading frame 40 PSMA7 20q133 proteasome (prosome, macropain) subunit, alpha type, 7 SS18L1 20q13.2-q13.3 synovial sarcoma translocation gene on chromosome 18-like 1 GTPBP5 20 GTP binding protein 5 (putative) HRH3 20q13.3 histamine receptor H3 OSBPL2 20q13.3 oxysterol binding protein-like 2 ADRM1 20q13.33 adhesion regulating molecule 1 LAMA5 20q13.2-q13.3 laminin, alpha 5 RPS21 20q13.3 ribosomal protein S21 C20orf150 20q13.33 chromosome 20 open reading frame 150 C20orf151 20q13.33 chromosome 20 open reading frame 151 GATA5 20q11.21-q11.22 GATA binding protein 5 RPL7P3 20q13.33 ribosomal protein L7 pseudogene 3 C20orf166 20q13.33 chromosome 20 open reading frame 166 FLJ30313 20q13.33 hypothetical protein FLJ30313 LOC388805 20 LOC388805 FLJ32154 20q13.33 hypothetical protein FLJ32154 SLCO4A1 20q13.33 solute carrier organic anion transporter family, member 4A1 NTSR1 20q13 neurotensin receptor 1 (high affinity) LOC391261 20 similar to putative glycine-rich protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 splicing 1410 42 407 - 2016 27827410
  • variant 1
  • encoding the same protein than variant 2
  • a 17 aa signal peptide of 1.7 kda
  • a 390 aa mature peptide of 40.5 kda
  • 10 splicing 1406 42 407 - 2016 27827410
  • variant 2
  • differing in the 5' UTR compared to variant 1
  • encoding the same protein than variant 1
  • a 17 aa signal peptide of 1.7 kda
  • 390 aa mature peptide of 40.5 kda
  • 9 - 1379 - 368 - 2016 27827410
    9 - 1375 - 368 - 2016 27827410
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   highly
    Lymphoid/Immunespleen   highly
    Nervousbrain   highly
    Respiratorylung   moderately
    Skin/Tegumentskin   predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectiveadipose  moderately
    Connectivebone   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • extracellular domain rich in serine and threonine residues
  • a conserved N-terminal region termed the pleckstrin-like receptor for ubiquitin domain (Pru)
  • a DEUBAD domain in ADRM1 activating UCHL5
  • a C-terminal half binding directly to the proteasome-associated deubiquitinating enzyme, UCHL5, and enhancing its isopeptidase activity, and containing KEKE motifs
  • C-terminal region of ADRM1 binds to the tetratricopeptide repeat (TPR) domain of SGTA, a cytosolic factor implicated in the quality control of mislocalised membrane proteins (MLPs)
  • conjugated GlycoP , Other
    mono polymer heteromer , complex
    isoforms Precursor heavily glycosylated, which increased the mass of the 42-kDa peptide to 110 kDa
    HOMOLOGY
    interspecies homolog to rattus Adrm1 (96.6 pc)
    homolog to murine Adrm1 (96.6 pc)
    Homologene
    FAMILY
  • GP110 family
  • ADRM1 family
  • CATEGORY adhesion , regulatory , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • promoting cell adhesion
  • playing an important role for the binding of UCHL5 to the 19S complex and for efficient proteolysis
  • recruiting UCHL5, a deubiquitinating enzyme known to associate with 26 proteasomes
  • having a specialised role in proteasome function
  • acting as an activator of proteasome
  • acting as a ubiquitin receptor in the proteasome
  • recruits UCHL5, a deubiquitinating enzyme known to associate with 26 proteasomes (Hamazaki 2006)
  • essential for the activity of UCHL5 (Hamazaki 2006)
  • required for cell migration and osteoclast maturation (Kim 2009)
  • proteasome subunit that functions as novel ubiquitin receptor (Kim 2009)
  • a new ATP6V0D2-interacting protein, playing an important role in osteoclast differentiation, and in particular the fusion of preosteoclasts (Kim 2009)
  • is an intrinsic ubiquitin receptor of the 26S proteasome regulatory subunit that facilitates substrate capture prior to degradation
  • ADMR1 and PSMD4 function as ubiquitin receptors of the proteasome
  • ADRM1 mostly plays a redundant role with PSMD4 in recognition of ubiquitinated proteins and maintaining likely homeostasis
  • ADMR1 and UCHL5 are implicated in cell cycle progression, providing a rationale for their function in cellular proliferation
  • role of ADMR1 as a proteasomal ubiquitin receptor
  • CELLULAR PROCESS nucleotide, transcription, elongation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS immunity/defense
    text
  • tumor antigen
  • RNA elongation from RNA polymerase II promoter
  • PATHWAY
    metabolism
    signaling
    a component
  • component of the regulatory ATPase complex of the 26 S proteasome
  • INTERACTION
    DNA
    RNA
    small molecule other,
  • ubiquitin
  • protein
  • binding C-terminal tail domain of UCHL5, and relieved the autoinhibition
  • proteasome interacting protein
  • interaction between ATP6V0D2 and ADRM1 (Kim 2009)
  • interacting with UCHL5 (Nishio 2009)
  • phosphorylated TP63 induces transcription of ADRM1, leading to NOS2 protein degradation
  • UCHL5 is a de-ubiquitinating enzyme that is activated by ADRM1 and involved in the proteasomal degradation of proteins
  • interaction of PSMD1 with ADRM1 is controlled by SUMOylation in a manner that may alter proteasome composition and function
  • ADMR1 can activate UCHL5 by disrupting dimerization, although physiologically relevant activation likely results from stabilization of a surface competent for ubiquitin binding and modulation of the active-site crossover loop
  • binding of SGTA to ADRM1 enables specific polypeptides to escape proteasomal degradation and/or selectively modulates substrate degradation
  • ADRM1 plays an important role in mediating removal of mutant Htt aggregates when excess HAPF8A140 is present
  • direct interaction between SGTA and the proteasome, mediated by the intrinsic proteasomal ubiquitin receptor ADRM1 (27827410)
  • is recruited to the proteasome through direct interaction with the large scaffolding protein PSMD1 within the 19S regulatory particle
  • binds ubiquitin with an affinity similar to that of other proteasome-associated ubiquitin receptors
  • PSMD1, ubiquitin, and the deubiquitylase UCHL5 bind to ADRM1 with independent energetics
  • F8A1 -mediated reduction of ADRM1 alters the mitochondrial fission activity and results in mitochondrial fragmentation and mitochondrial dysfunction
  • cell & other
    REGULATION
    induced by interferon gamma
    Other acetylated
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    expression induced by gamma-interferon in gastric carcinoma
    tumoral     --over  
    in high grade serous carcinoma (HGSC) of the ovary and serous tubal intraepithelial carcinoma (STIC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    novel therapeutic target for ovarian cancer
    ANIMAL & CELL MODELS